Microarrays, Genomics, and Systems Biology Keys to Science Institute – Molecular Biology and Biotechnology 2004
Scientific Disciplines • Biology • Molecular Biology • Biotechnology • Bioinformatics • Genomics • Systems Biology
The Challenge over Time • Identify a single gene (related to disease) • Identify as many, if not all, genes of an organism • Identify all sequence, including non-coding regions, contained within a genome • Consider how the kinds of scientific questions to be asked change.
GCAT • Genome Consortium for Active Teaching • Introduction to Microarrays • Animation
TIGR and Celera • The Institute for Genomics Research (TIGR) – non-profit, private • July 1995, first whole genome sequenced – Haemophilus influenzae 1.8Mb • Celera – for profit venture • celere is Latin for “swift” • shotgun sequencing
All information gleaned from: • Campbell, A. Malcolm and Laurie J. Heyer, “Discovering Genomics, Proteomics, and Bioinformatics”, ISBN 0-8053-4722-4 • Genome Consortium for Active Teaching (GCAT) website • TIGR powerpoint presentations • TIGR website