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General Microbiology M122

Big 400 students lecture Biology/Microbiology majors (JR, SR) + nursing students (SO). General Microbiology M122. Friday. Tuesday. Thursday. GOAL: To gain some insight into the role of microbial communities in human health.

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General Microbiology M122

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  1. Big 400 students lecture Biology/Microbiology majors (JR, SR) + nursing students (SO) General Microbiology M122 Friday Tuesday Thursday GOAL: To gain some insight into the role of microbial communities in human health

  2. LEARNING OBJECTIVE: To infer the relationship between human gut microbiome diversity, metabolism and environment Clickers, think-pair-share, group discussion Friday Tuesday Thursday Weekend Monday Wednesday In-class Out-of-class Practice exam questions Reading guide + pre-reading quiz Reading guide + pre-reading quiz

  3. LEARNING OBJECTIVE: To infer the relationship between human gut microbiome diversity, metabolism and environment

  4. In all the cases shown below, the populations in the upper panel are more diverse than the ones shown in the lower panel TRUE FALSE

  5. Data Discussion -What is a LF/PP diet? -What is a Western diet? -What are humanized gnotobiotic mice? -How did they run this experiment? Explain the timeline (what is in X-axis?) -What are they measuring on Y-axis? -what is acting as control here? Turnbaugh et al. 2009. The Effect of Diet on the Human Gut Microbiome: A MetagenomicAnalysis in Humanized GnotobioticMice. Sci Transl Med 1, 6ra14

  6. Your research indicates that bacteria that belong to the phylum Firmicutes have high capability to ferment refined sugars and digest fats. Bacteroidetes on the other hand, are better and degrading complex plant carbohydrates. You decide to run an experiment with humanized mice similar to the one we discussed in class: humanized mice growing in a Low fat/High plant carbohydrate diet are switched to a Western diet or kept on a Low fat/High plant carbohydrate diet as control. Based on this, you predict: • A. Bacteroideteswill dramatically increase in the gut of control mice kept in a Low fat/High plant carbohydrate diet • B. Firmicuteswill increase in the gut of humanized mice switched to a Western diet • Bacteroidetes will increase in the gut of humanized mice switched to a Western diet • C. a and b are correct • D. b and c are correct

  7. Reflection of one’s self in dialogue with its host Our Self Portrait: the Human Microbiome Oil on canvasTwo panels, 16 x 16 inby Joana Ricou , 2011 They are us, too

  8. Reflection of one’s self in dialogue with its course Our Courses Self Portrait Oil on canvasTwo panels, 16 x 16 inby Joana Ricou , 2011 Formative assessment should be there, too

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