sibyl
Uploaded by
9 SLIDES
282 VUES
90LIKES

Quantification of Tumor Hypoxia via [18F]-Fmiso PET: Correlating Imaging to Treatment Outcomes

DESCRIPTION

This study explores the quantification of tumor hypoxia using [18F]-Fmiso PET imaging and its correlation with treatment outcomes. We present dynamic Fmiso PET scans that exhibit distinct Time-Activity-Curves (TACs), as [18F]-Fluoromisonidazole selectively accumulates in hypoxic tissues. An analysis of the imaging data reveals that the tumor-to-blood ratio criterion for hypoxia is unreliable, emphasizing the need for kinetic analysis of the TACs. Our findings suggest that different TAC shapes correspond to various tumor architectures, illustrating the importance of perfusion and hypoxia mechanisms in treatment planning.

1 / 9

Télécharger la présentation

Quantification of Tumor Hypoxia via [18F]-Fmiso PET: Correlating Imaging to Treatment Outcomes

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Quantification of tumour hypoxia by [18F]-Fmiso PET and the correlation to treatment outcome Daniela Thorwarth and Markus Alber Section for Biomedical Physics, University Hospital for Radiation Oncology ESTRO 23, Amsterdam

  2. A(t) [kBq/cc] 10 0 20 10 FDG Fmiso (4h p.i.) 0 0 50 100 150 200 t[min] Dynamic Fmiso PET scans show different characteristic Time-Activity-Curves (TACs) Imaging hypoxia with [18F]-Fmiso [18F]- Fluoromisonidazole (Fmiso) accumulates selectively in tissue areas with low pO2 (≤10 mmHg)

  3. Analysis of Fmiso PET images A(t) [Bq/cc] Hypoxia criterion based on tumour-to-blood ratio ≥1.4 not reliable t [min] Kinetic analysis of the TACs is necessary

  4. fractional tumour volume accumu-lating Fmiso Compartment Model tissue fraction containing freely diffusive Fmiso k1 k2 k3 Fmiso content in the blood pool

  5. SCCNij 57 Perfusion SCCNij 107 A(t)[Bq/cc] Hypoxia SCCNij 51 Hypoxia /Necrosis J. Kaanders, UMC Nijmegen t [min] Charac-teristic shapes of TACs correspond to different structural architectures of the tumour

  6. Perfusion Decomposition determines thegrade ofPerfusionin the respectivetissue area Hypoxia concentration of Hypoxia in the considered volume Hypoxia/Necrosis diffusive compartment A(t) [Bq/cc] t [min]

  7. Scatter Plot Different Regions in Parameter Space correspond to characteristic TACs level of perfusion concentration of hypoxia perfusion hypoxia hypoxia/necrosis

  8. without local recurrence local recurrence Pat. 1 Pat.2 Pat. 7 Pat. 8 Pat. 3 Pat. 4 Pat. 9 Pat. 10 Pat. 5 Pat. 6 Pat. 11 Pat. 12 perfusion Pat. 13 Pat. 14 hypoxia concentration

  9. without local recurrence local recurrence Pat. 1 Pat.2 Pat. 7 Pat. 8 Pat. 3 Pat. 4 Pat. 9 Pat. 10 ? Pat. 5 Pat. 6 Pat. 11 Pat. 12 perfusion Pat. 13 Pat. 14 ? dose painting ? hypoxia concentration

More Related