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Rhodium(I)-Catalyzed Hydroacylation Promoted by Chelating Amines

Rhodium(I)-Catalyzed Hydroacylation Promoted by Chelating Amines Holly D. Bendorf , Lycoming College, Williamsport, PA 17701.

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Rhodium(I)-Catalyzed Hydroacylation Promoted by Chelating Amines

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  1. Rhodium(I)-Catalyzed Hydroacylation Promoted by Chelating Amines Holly D. Bendorf, Lycoming College, Williamsport, PA 17701 Benzazepines (n = 1) and benzazocines (n = 2) exhibit a broad range of biological activity. Our goal is to develop syntheses of these compounds that emphasize the efficient use of chemical resources, much of which are derived from petroleum. To this end, rhodium-catalyzed hydroacylation is an attractive strategy due to its inherent atom economy and mild reaction conditions. The chemistry developed in our laboratory exploits chelating allyl amines, which readily undergo hydroacylation and produce the desired compounds in moderate to high yields.

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