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Camila Andrea Gutiérrez Lina María Platero María Camila Supelano Tatiana Pulido Baron

27. Como funciona un inhibidor irreversible, explicar el mecanismo utilizando la aspirina como modelo. Camila Andrea Gutiérrez Lina María Platero María Camila Supelano Tatiana Pulido Baron. inhibidor irreversible.

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Camila Andrea Gutiérrez Lina María Platero María Camila Supelano Tatiana Pulido Baron

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  1. 27. Como funciona un inhibidor irreversible, explicar el mecanismo utilizando la aspirina como modelo Camila Andrea Gutiérrez Lina María Platero María Camila Supelano Tatiana Pulido Baron

  2. inhibidor irreversible • Destruyen un grupo funcional de la enzima que es esencial para su actividad. Forma una asociación covalente o no covalente muy estable • Es frecuente la formación de un enlace covalente entre: Inhibidor irreversible Enzima o

  3. Modelo de la aspirina • La aspirina funciona causando acilaciónirreversible de los residuos de serina 530 del sitio activo de la enzima COX previniendo la síntesis de prostaglandinas y tromboxanos.

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