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Evolutionary Pathways of Primordial Amino Acid Enzymes Fusion

Explore the functional association between Primordial amino acid kinases and N-acetyltransferases through ancestral carbamate kinases and N-acetyltransferase folds fusion. Studying the fusion of CK and NAT led to the formation of the NAGS enzyme with two-domain monofunctional or monodomain bifunctional characteristics. Evolutionary relationship insights on enzymes like ArgH(A), E. coli ArgB, E. coli ArgA, M. tuberculosis ArgA, and Moritella.

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Evolutionary Pathways of Primordial Amino Acid Enzymes Fusion

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  1. 250 aa 150 aa Primordial amino acid kinase Primordial amino acid N-acetyltransferase functional association Ancestral carbamate kinase fold (CK) Ancestral N-acetyltransferase fold (NAT) fusion fusion CK CK NAT NAT lyase fold NAT EC 2.7.2.8 EC 2.3.1.1 EC 2.3.1.1 EC 4.3.2.1 EC 2.3.1.1 N-acetylglutamate kinase NAGK two-domainmonofunctional NAGS monodomain monofunctional NAGS two-domain bifunctional ArgH(A) [E. coli ArgB] [E. coli ArgA] [M. tuberculosis ArgA] [Moritella]

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