1 / 3

Francesco NICOTRA

Francesco NICOTRA. Macchine Molecolari per il Trasporto e il Rilascio Selettivo di Farmaci.  DIPARTIMENTO DI BIOTECNOLOGIE E BIOSCIENZE. Fluorescent. Molecular Machinary for Drug Transport and Release. Iminosugars, RAS inhibitors Tyrosine kinase inhibitors. Folic acid RGD, …. Estrogens.

stefan
Télécharger la présentation

Francesco NICOTRA

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Francesco NICOTRA Macchine Molecolari per il Trasporto e il Rilascio Selettivo di Farmaci  DIPARTIMENTO DI BIOTECNOLOGIE E BIOSCIENZE

  2. Fluorescent Molecular Machinary for Drug Transport and Release Iminosugars, RAS inhibitors Tyrosine kinase inhibitors Folic acid RGD, …. Estrogens Drug ligand Linker internalisation -S-S- or acid labile or glucuronic acid or photolabile Endocytosis Permeabilization after cleavage Selective tansport mechanisms

  3. Protein (cell)-ligand bindingstudies by NMR L:P 20:1 1 mM : 50 μM 5+RAS-GDP STD-1D on-resonance freq. = 401.44 Hz 5+RAS-GDP 1H Peri F., Airoldi C., Colombo S, Mari S, Jiménez-Barbero J., Martegani E., Nicotra F. Chem. Eur. J., 2006, 3707

More Related