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This document outlines critical management strategies for addressing severe infections, emphasizing the elimination of the causative microorganisms and their sources. Key goals include providing hemodynamic and respiratory support, effective drainage of infected sites, and prompt empirical and targeted antibiotic therapy. Initial management involves broad-spectrum antibiotics, transitioning to specific agents based on blood culture results, with the inclusion of vancomycin for resistant strains. Additionally, interventions like intravenous fluid administration, transfusion of fresh frozen plasma, and oxygen therapy are vital to stabilize severely affected patients.
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Goals • elimination of the offending microorganism and its source • provision of hemodynamic and respiratory support
Elimination of causative agent • Drainage of the infection of focally infected site • Empherictheraphy while waiting for the result of blood culture and sensitivity • Use broadspectrum antibiotic ampicillini.v • After blood culture and sensitivity, use specific antibiotics sensitive to the causative agent • Use vancomycin if methicillin resistant
Hemodynamic support • Administration of i.v fluids • FFP in severe cases • Inotropics in severe hypotension
Respiratory support • Administration of oxygen in patients with respiratory distress • If oxygen saturation is still low despite administration of oxygen, intubatethe patient
