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Stroke

Stroke. John C. Stevenson Martin Birkhäuser Alfred O. Mueck. Stroke. 1. Risk factors, absolute risks 2. MHT – WHI, RCTs 3. MHT – Observational Studies 4. Tibolone, SERMs 5. Experimental Research 6. Stroke prevention, Guidelines, Consensus Statement. Stroke.

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Stroke

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  1. Stroke John C. Stevenson Martin Birkhäuser Alfred O. Mueck

  2. Stroke • 1. Risk factors, absolute risks • 2. MHT – WHI, RCTs • 3. MHT – Observational Studies • 4. Tibolone, SERMs • 5. Experimental Research • 6. Stroke prevention, Guidelines, Consensus Statement

  3. Stroke • 1. Risk factors, absolute risks • 2. MHT – WHI, RCTs • 3. MHT – Observational Studies • 4. Tibolone, SERMs • 5. Experimental Research • 6. Stroke prevention, Guidelines, Consensus Statement

  4. Increased stroke risk • Age • History/family history • Prior stroke, TIA, MI • Atrial fibrillation • Gender • Incidence greater in males • Mortality greater in females • Hypertension • Smoking • Diabetes mellitus • Arterial disease • Carotid, peripheral, coronary • Lifestyle • diet, exercise

  5. Stroke • Ischemic (thrombotic/embolic) • 86% • Hemorrhagic • Intracerebral 10% • Subarachnoid 4%

  6. Female stroke prevalenceUSA females, 2004 www.americanheart.org

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