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GSEC STUDY: CURRENT DATA ENTRY STATUS ( Last Update: October, 2005) Investigators 111

GSEC STUDY: CURRENT DATA ENTRY STATUS ( Last Update: October, 2005) Investigators 111 Studies 203 Total subjects 73,154 Cases 31,977 Controls 41 ,177 ===========================. DISTRIBUTION OF CANCER CASES IN THE DATA SET BY SITE SITE N (%)

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GSEC STUDY: CURRENT DATA ENTRY STATUS ( Last Update: October, 2005) Investigators 111

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  1. GSEC STUDY: CURRENT DATA ENTRY STATUS (Last Update: October, 2005) Investigators 111 Studies 203 Total subjects 73,154 Cases 31,977 Controls 41,177 ===========================

  2. DISTRIBUTION OF CANCER CASES IN THE DATA SET BY SITE SITEN (%) ----------------------------------------------------------- Lung 10,992 (34) Breast 4878 (15) Bladder 3753 (12) Head and neck 2912 (9) Colon 1930 (6) Skin 1632 (6) Leukemia 1646 (5) Prostate 873 (3) Ovary 148 (1) Uterus 490 (1) Others 2723 (8)

  3. Distribution of genetic polymorphisms available in the data-set

  4. EXAMPLE OF DATA AVAILABLE THROUGH GSEC

  5. HuGE – GSEC reviews

  6. Communication of results • Publications • Yearly e-mail to co-investigators • Web site

  7. METABOLIC GENE POLYMORPHISM FREQUENCIES IN CONTROL POPULATIONS Seymour Garte, Laura Gaspari, Anna-Karin Alexandrie, Christine Ambrosone, Herman Autrup, Judith L. Autrup, Helena Baranova, Lise Bathum, Simone Benhamou, Paolo Boffetta, Christine Bouchardy, Katja Breskvar, Jurgen Brockmoller, Ingolf Cascorbi, Margie L. Clapper, Christiane Coutelle, Ann Daly, Marco Dell'Omo, Vita Dolzan, Carolyn M. Dresler, Anthony Fryer, Aage Haugen, David W. Hein, Allan Hildesheim, Ari Hirvonen, Ling-Ling Hsieh, Magnus Ingelman-Sundberg, Ivan Kalina, Daehee Kang, Masahiro Kihara, Chikako Kiyohara, Pierre Kremers, Philip Lazarus, Loic Le Marchand, Maria Celeste Lechner, Ester M.M. van Lieshout, Stephanie London, Johannes J. Manni, Christine M. Maugard, Shunji Morita, Valle Nazar- Stewart, Kazumasa Noda, Yoshio Oda, Fritz F. Parl, Roberta Pastorelli, Irene Persson, Wilbert H. M. Peters, Agneta Rannug, Timothy Rebbeck, Angela Risch, Liliane Roelandt, Marjorie Romkes, David Ryberg, Jan Salagovic, Bernadette Schoket, Janeric Seidegard, Peter G. Shields, Edith Sim, Daniel Sinnet, Richard C. Strange, Isabel Stucker, Haruhiko Sugimura, Jordi To-Figueras, Paolo Vineis, Mimi C. Yu, and Emanuela Taioli.

  8. StrenghtsWeaknesses

  9. SOME RESULTS FROM GSEC ON EFFECTS OF METABOLIC GENE VARIANTS Association (O.R.) GSTM1, Smoking and Colorectal Cancer NS GSTM1, Head and Neck Cancer 1.3 GSTT1, Head and Neck Cancer 1.2 GSTM1, Smoking and Lung Cancer 1.1 NAT2 and Bladder Cancer 1.4 (interaction with smoking)

  10. THE WEB SITE (www.gsec.net) Was started at the time the study started Includes updates on data colelction, investigators who joined the group, publications deriving from the project, a medline on genetic susceptibility and cancer It is linked with the HuGE website

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