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Comprehensive Revision of T Cell Ontology and Classification

This revision presents an updated ontology for T cells, incorporating 34 types currently recognized in Cell Ontology. T cells are categorized into immature and mature subsets, along with alpha-beta and gamma-delta distinctions. The term "thymocyte" replaces "immature" for clarity, and definitions are refined to differentiate naïve from antigen-experienced T cells. Additional T helper subsets are introduced, highlighting transcription factors in their definitions. This comprehensive overview addresses cell development stages and includes essential markers like CD and transcription factors.

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Comprehensive Revision of T Cell Ontology and Classification

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  1. T cell ontology Revision

  2. T cells • 34 terms for types of T cell currently exist in the Cell Ontology. • Broadly divided into immature and mature subsets, and into alpha-beta and gamma-delta subsets. • The genus term ‘T cell’ is the parent term for all types of T cell.

  3. Immature T cells

  4. Mature T cells

  5. T Cell Ontology General issues for T cells • Introduce “thymocyte” to replace immature • Make definitions more precise. DN1 thymocyte - CD4- CD8- CD44+ CD25- • Introduce the concept of naïve versus antigen experienced T cell - instead of “mature” • Add additional T helper subsets - introduce transcription factors as part of the definition Changes made • Collapsed immature and mature T cell into the T cell term • Made definitions more precise. DN1 thymocyte - CD4- CD8- CD44+ CD25- • Added some generic terms such as helper T cell, memory T cell • A few cells have two parents • Expanded the development stages

  6. T cell overview

  7. T cell development

  8. NK T cells

  9. Definitions include CD markers and TFs

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