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Antiretroviral drugs in UMMC

Antiretroviral drugs in UMMC. Presenter: TE CHIN YEW Preceptor: KHOO SU LIN. Treatment goal. reduce HIV-associated morbidity and prolong the duration and quality of survival, restore and preserve immunologic function, maximally and durably suppress plasma HIV viral load , and

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Antiretroviral drugs in UMMC

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  1. Antiretroviral drugs in UMMC Presenter: TE CHIN YEW Preceptor: KHOO SU LIN

  2. Treatment goal • reduce HIV-associated morbidity and prolong the duration and quality of survival, • restore and preserve immunologic function, • maximally and durably suppress plasma HIV viral load, and • prevent HIV transmission.

  3. Life cycle of HIV and targets for antiretroviral drugs.

  4. Lamivudine (3TC) • 150mg BD • Brand name: 3TC • OP

  5. Zidovudine (AZT) • 300mg BD • Brand name: Zidovudine • Side effects: Bone marrow suppression: macrocytic anemia/neutropenia; GI intolerance, headache, insomnia, asthenia • OP

  6. Stavudine (d4T) • 30mg BD • Brand name: Stavudine Capsules USP • Side effects: Peripheral neuropathy, lipodystrophy, panreatitis, lactic acidosis with hepatic steatosis, hyperlipidemia • OP

  7. Tenofovir • 300mg OD • Brand name: Tenvir • Side effects: asthenia, headache, diarrhea, nausea, vomiting, flatulance, renal insufficiency • Kedai PharmUMMC

  8. Efavirenz (EFV) • 600mg ON • Brand name: Stocrin • Side effects: rash, CNS symtoms (insomnia, irritability, lethargy, dizziness, vivid dreams), increase LFT • OP

  9. Nevirapine (NVP) • 200mg BD • Brand name: Nevirapine Tablets USP • Side effects: rash including Steven-Johnson Syndrome, symptomatic hepatitis (including fatal hepatic necrosis) • OP

  10. Indinavir • 800mg TDS • Brand name: Crixivan • Side effects: Nephrolithiasis, GI intolerance, nausea, hyperlipidemia, headache, asthenia, blurred vision, dizziness, metallic taste, thrombocytopenia, alopecia, hyperglycemia, fat maldistribution • OP

  11. Ritonavir • 600 mg BD • Brand name: Norvir • Side effects: GI intolerance, nausea, diarrhea, paresthesias, hyperlipidemia, hepatitis, asthenia, hyperglycemia, fat maldistribution • Kedai PharmUMMC

  12. Darunavir • 600mg BD • Brand name: Prezista • Side effects: skin rash, diarrhea, nausea, headache, hyperlipidemia, hyperglycemia, fat maldistribution • Kedai PharmUMMC (Study)

  13. Atazanavir • 400mg OD • Brand name: Reyataz • Side effects: prolonged PR interval, hyperglycemia, fat maldistribution • Kedai PharmUMMC (Study)

  14. Raltegravir • 400 mg BD • Brand name: Isentress • Side effetcs:headache, fatigue, dizziness, pruritis • Kedai PharmUMMC

  15. Combination drugs

  16. Zidovudine + Lamivudine • 1 tab BD • Brand name: Combivir • OP

  17. Tenofovir + emtricitabine (Truvada) • 1 tab OD • Brand name: Tenvir-EM • Kedai PharmUMMC

  18. Lopinavir + ritonavir • 2 tabs BD • Brand name: Kaletra • Kedai PharmUMMC

  19. Stavudine + Lamivudine + Nevirapine • 1 tab BD • Brand name: SLN • OP

  20. LASA

  21. References: • Marie A. Chisholm-Burns, et. al. 2007. Pharmacotherapy principles & practice. Mc. Graw Hill. • Department of Health and Human Services (DHHS)( Guidelines. (http://aidsinfo.nih.gov) • PPUM Drug Formulary

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