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Outcomes of Therapeutic Trials in Mouse Models of PTOA: An Overview of Genetic Modifications

This article reviews the outcomes of therapeutic trials conducted on mouse models of post-traumatic osteoarthritis (PTOA), specifically focusing on studies lacking data regarding genetic modifications. It highlights the translational challenges faced when moving from these animal models to clinical trials, emphasizing the need for better genetic insight to improve treatment efficacy. The findings underline the importance of comprehensive data collection in preclinical studies to enhance our understanding and management of PTOA in human subjects.

sydney-fleming
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Outcomes of Therapeutic Trials in Mouse Models of PTOA: An Overview of Genetic Modifications

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  1. Table 3 Outcomes of therapeutic trials in mouse models of PTOA lacking data on genetic modification Little, C. B. & Hunter, D. J. (2013) Post-traumatic osteoarthritis: from mouse models to clinical trials Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2013.72

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