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Quercetina

Quercetina. Phytoestrogens. Benassayag, et al., 2002. J. Chromatogr.B 777:233-248. Comparison of binding affinities and transactivation of estrogen and phytoestrogens. Belcher & Zsarnovszky, 2001. J. Pharmacol. Exp. Therap. 299:408-414. La quercetina e’ un flavonoide ubiquitario nei vegetali

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Quercetina

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  1. Quercetina

  2. Phytoestrogens Benassayag, et al., 2002. J. Chromatogr.B 777:233-248.

  3. Comparison of binding affinities and transactivation of estrogen and phytoestrogens Belcher & Zsarnovszky, 2001. J. Pharmacol. Exp. Therap. 299:408-414

  4. La quercetina e’ un flavonoide ubiquitario nei vegetali Causa arresto della proliferazione di cellule tumorali Le cellule si arrestano in G1 L’arresto della crescita sembra essere dovuto ad apoptosi (si osserva rilascio di citocromo c nel citoplasma)

  5. H1299 e A549 sono due linee cellulari derivate da tumori del polmone

  6. Le frecce indicano i nuclei apoptotici (colorati in blu)

  7. La quercetina causa un arresto in G2/M in carcinoma polmonare

  8. Genisteina

  9. Phytoestrogens Benassayag, et al., 2002. J. Chromatogr.B 777:233-248.

  10. Comparison of binding affinities and transactivation of estrogen and phytoestrogens Belcher & Zsarnovszky, 2001. J. Pharmacol. Exp. Therap. 299:408-414

  11. ICI = composto antiestrogenico

  12. Attivazione di p53 in un linfoblastoma (S= citoplasma; P= nucleo)

  13. EMSA di p53 in un linfoblastoma (S= citoplasma; P= nucleo)

  14. Attivazione di p21 in un linfoblastoma (S= citoplasma; P= nucleo)

  15. Genisteina Risposta in seguito a danno su DNA P53 P21 Arresto in G1

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