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Structural Insights into Viral Proteins: Hemagglutinin and Neuraminidase

This review explores the up-and-down beta-barrel structures and the functional aspects of key viral proteins, including superoxide dismutase, plasma retinol-binding protein, neuraminidase, and hemagglutinin. We delve into the binding sites, structural motifs such as the Greek key, and the tetrameric subunit structures of influenza neuraminidase and hemagglutinin. The interactions at low pH and conformational changes related to fusion peptide functionality are highlighted. Key amino acid sequences are also discussed to illustrate their significance in structural biology.

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Structural Insights into Viral Proteins: Hemagglutinin and Neuraminidase

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  1. b Structures

  2. Up-and-down b barrel

  3. Superoxide dismutase

  4. Up-and-down b barrel

  5. Plasma retinol-binding protein (RBP)

  6. Binding site for retinol inside RBP barrel

  7. Amino acid sequence of b strands 2 3 4 in RBP

  8. Neuraminidase from influenza virus

  9. Subunit structure of neuraminidase headpiece (84-469)

  10. Tetrameric Neuraminidase

  11. Neuraminidase-active site

  12. Greek key motif

  13. Greek key motif-two possibilities

  14. g-crystallin

  15. g-crystallin

  16. g-crystallin

  17. g-crystallin

  18. g-crystallin

  19. Jelly roll barrel(Swiss roll)

  20. Single subunit of influenza virus hemagglutinin

  21. Hemagglutinin

  22. Trimers of Hemagglutinin

  23. Sialic acid

  24. Distorted jerry roll structure of hemagglutinin globular head

  25. Inhibitor-hemagglutinin

  26. Hemagglutinin at low pH

  27. Conformational change between high & low pH forms of hemagglutinin

  28. Where is fusion peptide ?

  29. Tamm Laboratory at http://faculty.virginia.edu/tamm/pages/project_fusion.html

  30. Cell Vol 89, p263 (1997) Chan et al.Core Structure of gp41 from the HIV Envelope GlycoproteinThe envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1) consists of a complex of gp120 and gp41. gp120 determines viral tropism by binding to target-cell receptors, while gp41 mediates fusion between viral and cellular membranes.

  31. Parallel b-helix

  32. Two sheet b-helix

  33. Three sheet b-helix

  34. Pectate lyase C

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