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APP: therapeutic target. sAPP alpha: neurotrophic role. N-ter. Neuroprotection against tauopathy. sAPP beta. APP. 1: Ab e ta oligomers. 2b B eta secretase (BACE1). Extracellular domain. 3 Alpha secretase. No Abeta formation. Ab e ta. Gamma secretase. Gamma secretase 2a. 4
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APP
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APP: therapeutic target sAPPalpha: neurotrophic role N-ter Neuroprotection against tauopathy sAPP beta APP 1: Abeta oligomers 2b Beta secretase (BACE1) Extracellular domain 3 Alpha secretase No Abeta formation Abeta Gamma secretase Gamma secretase 2a 4 Turn- over Alpha stub C-ter AICD transcription factor: neprilysin,… AICD Beta stub Intracellular domain Amyloidogenic pathway: the evil Non-amyloidogenic pathway: the good
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