1 / 1

APP

APP: therapeutic target. sAPP alpha: neurotrophic role. N-ter. Neuroprotection against tauopathy. sAPP beta. APP. 1: Ab e ta oligomers. 2b B eta secretase (BACE1). Extracellular domain. 3 Alpha secretase. No Abeta formation. Ab e ta. Gamma secretase. Gamma secretase 2a. 4

taniel
Télécharger la présentation

APP

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. APP: therapeutic target sAPPalpha: neurotrophic role N-ter Neuroprotection against tauopathy sAPP beta APP 1: Abeta oligomers 2b Beta secretase (BACE1) Extracellular domain 3 Alpha secretase No Abeta formation Abeta Gamma secretase Gamma secretase 2a 4 Turn- over Alpha stub C-ter AICD  transcription factor: neprilysin,… AICD  Beta stub Intracellular domain Amyloidogenic pathway: the evil Non-amyloidogenic pathway: the good

More Related