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Lookback study for transfusion-related HBV infection in Japan

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tarmon
13 diapositives · 287 Views · Sep 01, 2014

This study explores the incidence of transfusion-related hepatitis B virus (HBV) infections from donations at the Tokyo Metropolitan Red Cross Blood Center. Analyzing aliquots stored since 1997, the research investigates cases of HBs-Ag and HBc-Ab converters alongside individual donation NAT (ID-NAT) results. It estimates the infectivity of HBV-ID-NAT positive components and reviews outcomes in transfused patients. The findings indicate significant risks standard screening may overlook, highlighting the importance of improved monitoring and public health strategies.

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  1. Lookback study for transfusion-related HBV infection in Japan Tokyo Metropolitan Red Cross Blood Center Masahiro Satake

  2. Aliquots from all donations have been stored since 1997. When necessary, each aliquot was investigated using individual donation-NAT (ID-NAT). Subjects for the study : converters for HBs-Ag, HBc-Ab, HCV-Ab, HIV-Ab, screening NAT for HBV, HCV or HIV during April 1999 and February 2005 Lookback study in Japan

  3. ID-NAT results in repository tubes from seroconverted or NAT-converted donors (‘99 April ~ ’05 February)

  4. No. of HBV ID-NAT positive but pool-NAT negative donors estimated by lookback study These donations do not directly relate to infectivity.

  5. The infectivity of HBV-ID-NAT positive components No. of ID-NAT positive donation267 No. of components released 321 transfused・・・・・・・・・・・ discarded・・・・・・・・・・・ unknown・・・・・・・・・・・ Outcome of transfused patients（191 reports available） HBs-Ag conversion HBV-DNA conversion HBs-Ab conversion positive, but no information before transfusion 7 markers not changed dead discharged etc. 293 16 12 6 2 3 60 99 14

  6. The infectivity of HBV-ID NAT-positive components HBV infected Undetermined No change others 11 7 60 115 Infectious risk when transfused with ID-NAT positive blood 11／78～18 ／78 6～10 HBV infections per year

  7. Infectivity of HBV ID-NAT positive components Infectivity of W.P. component is 13 times as high as that from chronic carrier.

  8. Implicated components

  9. Established cases for HBV infection Disorders of patients hematologic malignancy 2 gastric cancer 2 dissecting aortic aneurysm 1 shock due to multiple trauma 1 rheumatoid arthritis 1 unknown 4

  10. ID-NAT in repository tubes --- voluntarily reported HBV cases ---

  11. The risk of HBV infection under current screening algorism including 50p-NAT system

  12. Lookback study for HCV and HIV Seroconversion possibly due to nonspecific reaction was also subjected to lookback study.

  13. Estimates for the Occurrence of Transfusion-Transmitted Viral Diseases in Japan • HBV • HBV+ donation detectable only by ID-NAT : 1 / 150,000 • 11～15 infection cases per year • 　　 （1 infection / 3.6～5.4 x 105 components） • HCV　（difficult to estimate） • HCV+ donation detectable only by ID-NAT : 1 / 24 million （1 component / 4 years） • HIV　（difficult to estimate） • HIV+ donation detectable only by ID-NAT : 1 / 12 million （1 component / 2 years）