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214. 2479. 4745. 7011. 9276. 11540. -15. -10. -5. 0. 5. 10. 15. 20. 25. 30. 0.20. 0.15. Lac. 0.10. m -Ino. 0.05. 0.00. -0.05. -0.10. -0.15. 12000. 10000. 8000. 6000. 4000. 2000. 0. 0. 2000. 4000. 6000. 8000. 10000. 12000. A. 10. ●. ●. ●. ●. ●. ●. ●.

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  1. 214 2479 4745 7011 9276 11540 -15 -10 -5 0 5 10 15 20 25 30 0.20 0.15 Lac 0.10 m-Ino 0.05 0.00 -0.05 -0.10 -0.15 12000 10000 8000 6000 4000 2000 0 0 2000 4000 6000 8000 10000 12000 A 10 ● ● ● ● ● ● ● 5 ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● 0 ● ● ● ● ● ● ● ● ● ● Score of PC2 ● ● -5 ● -10 ● ● ● ● -15 ● -20 ● ● -25 Score of PC1 B Cre PC GPC Cre Tau -Glc Loading of PC1 Cho 0 200 400 600 800 1000 1200 1400 Chemical shift C ● ● ● Predicted tumor cell density (cells/mm2) ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● r = 0.80 p < 0.001 ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● Measured tumor cell density (cells/mm2)

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