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Hemostasis

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  1. Hemostasis • platelet plug formation • vasoconstriction • blood coagulation

  2. PlateletFormation Fig. 18.20 Fig. 27-2 Ganong

  3. Platelet Activation and Platelet PlugFormation Fig. 18.21

  4. CoagulationMechanisms Fig. 18.23

  5. Common Mechanism Fig. 18.23 Fig. 18.22

  6. Extrinsic Mechanism Fig. 18.23

  7. Intrinsic Mechanism Fig. 18.23

  8. CoagulationMechanisms positive feedback • Figure 27–24 Ganong. • The clotting mechanism. a, active form of clotting factor. TPL, tissue thromboplastin; TFI, tissue factor pathway inhibitor. For other abbreviations, see Table 27–8.

  9. Hemostasis: Various Topics • Clot retraction • Clot dissolution • plasmin / plasminogen activator • Thrombus / Thrombotic Embolus • Anticoagulants • aspirin • heparin • oxalate/citrate/EDTA • coumarins Fig. 27-25, modified Ganong