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Understanding Two-Component Signaling Systems in Cellular Response Mechanisms

This overview discusses the Two-Component Signaling (2CS) paradigm, which is fundamental in bacterial response mechanisms. It highlights the role of sensor proteins that detect environmental stimuli and regulate responses through a series of phosphorelay reactions. The process begins with autophosphorylation of the sensor in response to stimuli, followed by phosphotransfer to a response regulator, and concludes with the deactivation of the response regulator by phosphatase, effectively resetting the system. Examples include osmoregulation and light-sensing devices.

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Understanding Two-Component Signaling Systems in Cellular Response Mechanisms

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  1. 2 Component Signaling 20.20(S11) N Kuldell

  2. As simple as the box it comes in…

  3. The 2CS paradigm: in general Sensor protein Response regulator

  4. The 2CS paradigm: Phosphorelay rxns Slide from Mike Laub

  5. The 2CS paradigm: Phosphorelay rxns Sensor Sensor Sensor Sensor P Responder (inactive) P Responder RXN 1: Autophosphorylation in response to stimuli RXN 2: Phosphotransferase from Sensor to Response regulator RXN 3: Phosphatase inactivates Response regulator, resets system

  6. 2CS examples: Osmoregulation 2CS transduction, Hoch and Silhavy

  7. As simple as the box it comes in… Color Generating Device Light Sensing Device

  8. As simple as the box it comes in… Color Generating Device Light Sensing Device

  9. the end

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