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數學模擬與系統生物

Final Project. 數學模擬與系統生物. Gene Regulatory Networks and the Evolution of Animal Body Plans. GRNs. GRNs: large gene regulatory networks Control development of the animal body Evolution of body plans depend upon architecture of development GRNs. Pleiotropic.

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數學模擬與系統生物

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  1. Final Project 數學模擬與系統生物 Gene Regulatory Networks and the Evolution of Animal Body Plans

  2. GRNs • GRNs: large gene regulatory networks • Control development of the animal body • Evolution of body plans depend upon architecture of development GRNs

  3. Pleiotropic • Pleiotropy describes the genetic effect of a single gene on multiple phenotypic traits.

  4. Example of Cambrian body plans from the Early Cambrian

  5. GRN component • Kernels • Plug-ins • Switches (I/O devices) • Differentiation gene batteries

  6. GRN kernels • Network subcircuits that consist of regulatory genes • Kernels are dedicated to given development of the organism • Kernels have particular form of strcture

  7. Plug-ins • “Plug-ins” consist of GRN subcircuits • Provide inputs into regulatory apparatus

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