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Ne w S ampling/ S ensor I nitiative ( NeSSI ™) Analytical Applications and Web Tools

Ne w S ampling/ S ensor I nitiative ( NeSSI ™) Analytical Applications and Web Tools. Dave Veltkamp, CPAC. Overview of Talk. Discuss how NeSSI™ can facilitate laboratory applications and how current development fits lab needs

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Ne w S ampling/ S ensor I nitiative ( NeSSI ™) Analytical Applications and Web Tools

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  1. New Sampling/Sensor Initiative (NeSSI™)Analytical Applications and Web Tools Dave Veltkamp, CPAC

  2. Overview of Talk • Discuss how NeSSI™ can facilitate laboratory applications and how current development fits lab needs • Examples of NeSSI™ as a platform for micro analytical devices and analyzers • Mention some web-based resources at CPAC

  3. What does NeSSI™ Provide • Simple “Lego-like” assembly • Easy to re-configure • No special tools or skills required • Standardized flow components • “Mix-and-match” compatibility between vendors • Growing list of components • Standardized electrical and communication (Gen II) • “Plug-and-play” integration of multiple devices • Simplified interface for programmatic I/O and control • Advanced analytics (Gen III) • Micro-analyzers • Integrated analysis or “smart” systems

  4. P V NeSSI™: Enabler for MicroAnalytical (the “rail” concept) Standard “connectivity” Standard Electrical (Digital) Interface “Rail” SAM* Standard “hockey-puck PC” Anyone’s Actuator Anyone’s Sensor Standard Mechanical Interface “Rail” *Sensor/Actuator Manager

  5. Where Does NeSSI™ Fit in the Lab • Instrument/Sensor Interfaces • Design standards make development simpler • Reduced toolset to be mastered • Reduced sample variability to account for • Calibration/validation built-in • Consistent physical environment for measurement • Stream switching and/or mixing allow generation of standards to match analytical requirements • Reaction monitoring • Microreactors and continuous flow reactors • Batch reactors (with fast loop) • Sample Preparation • Gas handling (mixing, generation, delivery) • Liquid handling (mixing, dilution, conditioning, etc.)

  6. Special Lab NeSSI™ Requirements • Flowing streams • Need to move liquid and gas streams through NeSSI™ • Most laboratory analysis involves discrete samples rather than sample streams • Analytical characterization of flow in NeSSI™ needed • Heating and Cooling • Laboratory applications need both • May require more rapid thermal response • Integration with other lab apparatus • Serial communication and legacy I/O • Integration with lab software systems • Low cost • Competing with other solutions that don’t carry some of NeSSI’s more exotic features

  7. NeSSI™ and Microreactors • Investigate integration of NeSSI™ with continuous flow microreactors • Initially as analyzer interface • Eventually as complete fluidics framework • Automation requires Gen II

  8. Initial Sensor Integration Continuous Microreactor Online Raman Probe Sample Flow Cell Initial Sensor Integration

  9. NeSSI Raman Sampling Block • Parker Interflow NeSSI substrate • Sample conditioning to induce backpressure to reduce bubble formation and the heated substrate allows analysis at reactor conditions

  10. NESSI Microreactor Sampling/Calibration System Reactor Feed 1 Pump 1 Product Stream Reactor Feed 2 Real-time Calibration waste prod Raman Probe Pump 2

  11. Benefits of NeSSI™ to Reaction Analysis • Conditioning and manipulation of sample introduced to analyzer • Better control of sample physical parameters • Phase • Temperature • Velocity • Ability to implement sensors at points where measurement parameters are optimal • Flexibility for performing calibration online without removing sensor • Fast switching of streams for measurement, calibration or validation

  12. NeSSI™ Fermentation System • Switching filter system to handle particulate laden liquid streams • Cells in fermentation broth • Supplied by Bob Sherman, Circor • Interested in plugging, cleaning, and other issues related to bio/pharma applications 2Filters

  13. MFC Calibration gases MFC ToMassSpec MFC MFC MFC Fermentor Headspace Loop Fermentation Headspace System • Designed to allow fermentation headspace monitoring • Fast circulation loop of headspace gases • Addition of calibration gases • Output to process Mass spectrometer

  14. Example Sensor Interface • Sensor is a vapochromatic compound • Responds to different compounds by intensity and wavelength shifts in fluorescence signal • Optical detection using simple VIS spectrometer • LED excitation light source • Simple reflection optical fiber light path • Use of BallProbe to provide single-sided optical interface • Vapochrome coated on ball surface • NeSSI™ system to control delivery and mixing of gas stream

  15. NeSSI Gas Mixing System Using a customized ballprobe reflectance probe for vapochromic detection • Ocean optics spectrometer • ballprobe coated with vapochrome - NeSSI substrate with 2 MFC’s

  16. Experiment • 25 ms • 20 accums • Experiment • 25 ms • 20 accums 800 800 Dry N2 600 600 Intensity (counts) Air Air 400 400 200 200 600 600 650 650 700 700 750 750 800 800 850 850 Wavelength (nm) NeSSI Gas Mixing System Fluorescence response of vapochrome to dry N2 and cylinder air

  17. Vapochromic Response Movie

  18. Vapochrome Summary • Use of NeSSI™ system allowed for better control and characterization of sensor response • Less variability and faster response to gas composition changes • Ability to generate gas mixtures in situ • Opens up potential for additional studies to quantitatively characterize a library of vapochromatic compounds to different analytes • Investigate optimal sensor design

  19. NeSSI™ Knowledge Network • Main topic page divided into 4 sections • News and Information • Discussion (NeSSI Q&A) • Component List • Only Manufacturers group may post here • Testing and Examples • Main NeSSI™ web site • http://www.cpac.washington.edu/NeSSI.htm • NKN can be found at • http://www.cpac.washington.edu/NeSSI/NKN.html

  20. Component List Sub-topics • Page shown from the “Valve, Manual” topic • Listing of topics under manual valve main topic • Number of posts will correspond to different available components

  21. Component List Page • Example post from the component list page • URL from Vendor • Spec. sheet or link • Picture, description, or link to more information • Other Vendors are currently working to populate the list with more components

  22. User Self-Registration • Allows users to setup accounts • Selecting to join “Manufacturers” group will queue user’s registration until a moderator approves it. • Membership in other groups automatically approved immediately • Profile data will be used for NeSSI™ mailing list • Check the options available from the “Edit Profile” link once user activates account • Once user submits registration form, they are sent an email with instructions for activating their new account • Your account is not active till you log in and follow the instructions in the email

  23. NKN Conclusion • New software and web site ready to be used • Need to work on additional instruction sheets • Thanks to Michelle Cohn, UOP for helping CPAC buy a new server to host NeSSI™ and NKN web sites • NeSSI Component List is becoming populated • Major manufacturers already signed up and starting to supply content • Need to get smaller suppliers to do the same • Need to get user community to register and start using it • Expect Email announcements soon (1-2 weeks)

  24. NeSSI™ Sensor Survey • The purpose of this survey is to gather information on the sensors and actuators needed for NeSSI Generation II Sample Systems, Analytical Systems, and Cluster Applications.  • This data will be shared with sensor and instrument vendors to help them prioritize development of the devices needed across industries and applications.  • The more information you can provide, the faster better products and performance can be delivered

  25. NeSSI™ Sensor Survey (cont.) • On-line survey form on the CPAC NeSSI™ web site • http://www.cpac.washington.edu/NeSSI/CPAC_NeSSI_Sensor_Survey.htm • Questions about condition sensors • Are you interested • How would you rank their importance • Operating ranges • Questions about analytical sensors • Are you interested • How would you rank their importance • Operating ranges • Questions about actuators • Questions about “Clusters” • Optional contact information

  26. NeSSI™ Sensor Survey Results • Condition Sensors • Analytical Sensors

  27. NeSSI™ Sensor Survey Results • Actuators • Clusters • 11 of the 15 respondents indicated they would share information with Vendors

  28. NeSSI™ Sensor Survey (cont.) • Plan is to continue to solicit responses from users • Additions to survey questions or content welcome • May expand survey activities to help provide market directions to suppliers • Other aspects of NeSSI™ development • Applet Software and other issues relate to SAM • New opportunities or innovations • Need to reach beyond the normal NeSSI™ enthusiasts • Combined with the discussion board, surveys provide a valuable resource for both end-users and manufacturers of NeSSI

  29. Summary & Conclusion • NeSSI™ Gen II ready for development • Working spec/prototype design complete • Prototypes demonstrated in real applications • Near resolution of the NeSSI™ bus issue • For some laboratory applications • Gen II and Gen III will immediately work and provide benefits • The future holds a lot of promise!!

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