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The Clinical Significance of Nuclear YAP Expression in Hepatocellular Carcinoma

The Clinical Significance of Nuclear YAP Expression in Hepatocellular Carcinoma. 徐 智 南京医科大学附属南京第一医院暨 南京市第一医院 肿瘤内科. Worldwide incidence of HCC. Blum HE, Spangenberg HC. Arch Iran Med . 2007 Jul;10(3):361-71. Identification of Yes-associated Protein (YAP). E. G. F. H.

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The Clinical Significance of Nuclear YAP Expression in Hepatocellular Carcinoma

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  1. The Clinical Significance of Nuclear YAP Expression in Hepatocellular Carcinoma 徐 智 南京医科大学附属南京第一医院暨 南京市第一医院 肿瘤内科

  2. Worldwide incidence of HCC Blum HE, Spangenberg HC. Arch Iran Med. 2007 Jul;10(3):361-71.

  3. Identification of Yes-associated Protein (YAP) E G F H Zender, L. et al.Cell 125, 1253-67

  4. Time (Days) YAP improves cell proliferation *：p<0.05。

  5. YAP induces anchorage-independent growth MIHA-YAP cells but not MIHA-Vec could form colonies in soft-agar.

  6. YAP enhances cellular mobility and invasiveness MIHA-YAPcells gained advantages in cell migration and invasion.

  7. IHC results of YAP in HCC 53.7% HCC samples showed nuclear YAP positive.

  8. Clinical association of nuclear YAP in HCC

  9. Clinical association of nuclear YAP and HCC-specific postsurgical recurrence Kaplan-Meier Median RFT： Nuclear YAP negative: 25.8 months vs. Nuclear YAP positive：12.9months

  10. Cox Regression Nuclear YAP is an independent prognostic marker for HCC recurrence

  11. Summary • YAP confers tumorigenic and metastatic potentials in hepatocytes, as evidenced by enhanced aptitudes in cell viability, anchorage-independent growth, migration and invasion. • YAP nuclear accumulation was found in the 53.7% of HCC, correlated with poorer tumor differentiation and higher serum alpha-fetoprotein (AFP) levels. • Nuclear YAP is an independent predictor for HCC-specific recurrence-free survival. • YAP plays an important role in HCC development and progression.

  12. Acknowledgement • 新加坡国立大学外科系和药学系 Asso. Prof. John M. Luk • 香港大学外科系 Prof. Fan S. T.，Prof. Poon R. T. and Surgical Tissue Bank • 南京市第一医院肿瘤内科

  13. Thank You

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