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Comparison of QFI Using TBP and FTH1 Loci in Cancer Samples

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This study compares QFI values from TBP and FTH1 loci in 62 FFPE cancer samples, showing strong correlation and agreement. Samples with QFI>3% had fold change consistent with lack of significant copy number alterations.

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Comparison of QFI Using TBP and FTH1 Loci in Cancer Samples

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  1. Supplemental Figure 2: Comparison of QFI using amplification loci in TBP (119 bp) and FTH1 (119 bp). A subset of sixty-two (62) FFPE samples representing all six cancer types described in the primary study were assessed using both TBP and a second gene target, ferritin heavy polypeptide 1 (FTH1). A Pearson correlation of 0.88 and a slope of 1.0 was observed between the QFI values determined for these two genes, reflecting strong agreement. None of the samples with a QFI>3% had a fold change <0.5 or >2.0 consistent with a lack of a significant copy number amplification or deletion in one or the other loci. The 95% CI of fold change in QFI was 0.8-1.04. Slope = 1.01 R = 0.88 % QFI—TBP 95% CI (0.80-1.04) Fold Change (FTH1/TBP) % QFI—FTH1

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