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Handling of Radiopharmaceutical’s in Hospital

Handling of Radiopharmaceutical’s in Hospital. Presented By:- Deepa Kumari Karn M pharm (C.P), First Semester. Contents. Introduction Uses Properties Advantages and Disadvantages Important Radiopharmaceuticals Procurement Compounding and Dispensing Handling and storage

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Handling of Radiopharmaceutical’s in Hospital

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  1. Handling of Radiopharmaceutical’s in Hospital Presented By:- DeepaKumariKarn M pharm (C.P), First Semester

  2. Contents • Introduction • Uses • Properties • Advantages and Disadvantages • Important Radiopharmaceuticals • Procurement • Compounding and Dispensing • Handling and storage • Discard of Radiopharmaceuticals • References

  3. Introduction • Pharmaceutical formulations consisting of radioactive substances (radioisotopes and molecules labeled with radioisotopes) • Essential component of the nuclear medicine practice

  4. Composed of the radioactive isotope and a carrier molecule • Radiopharmacy practice combines the expertise of pharmaceutical preparation and the skills needed to handle radioactive substances • Due to the short half and rapid decay, they must be prepare shortly before their clinical use and comprehensive quality control of the final product can’t be performed

  5. Uses • Diagnosis • The radiopharmaceuticals are injected to the vein, emits the gamma radiations as it decay and the gamma camera scan the radiation and create the image and the functional information of the target organ

  6. Treatment • β-ray energy from the radioisotope is delivered to the target tissue partially or completely destroy the diseased tissue

  7. Properties of ideal Radiopharmaceuticals • Short physical half life time • Eliminated from the body with an effective half life time approximately equaling the examination time to prevent subsequent exposure to the body • Pure gamma emitter by isometric transition • Gamma rays emitted should be mono-energetic and highly specific activity

  8. Localize largely and quickly at the target site and decay into a more stable daughter nucleus • Easily and effectively attached to the chemical compound at room temperature and cheap per patient dose

  9. Advantages and Disadvantages • Advantages • Used for both diagnostic as well as treatment purpose • Used for the treatment of the cancer as well as bone metastasis • Provide the fast onset and single dose may be sufficient for the treatment • No side effect and completely safe

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