1 / 8

BIOEQUIVALENCE OF TOPICAL DRUGS: USE OF THE CADAVER SKIN MODEL

BIOEQUIVALENCE OF TOPICAL DRUGS: USE OF THE CADAVER SKIN MODEL. Thomas J. Franz M.D. Dermtech International San Diego, CA 92128. CADAVER SKIN MODEL. Widely used to optimize topical formulations, maximize BA Able to measure rate and extent of drug absorption through skin

tessa
Télécharger la présentation

BIOEQUIVALENCE OF TOPICAL DRUGS: USE OF THE CADAVER SKIN MODEL

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. BIOEQUIVALENCE OF TOPICAL DRUGS: USE OF THE CADAVER SKIN MODEL Thomas J. Franz M.D. Dermtech International San Diego, CA 92128

  2. CADAVER SKIN MODEL • Widely used to optimize topical formulations, maximize BA • Able to measure rate and extent of drug absorption through skin • 40-year experience with the model • Good in-vitro to in-vivo correlation

  3. COMPARISON OF CLINICAL AND CADAVER SKIN DATA • Validation of cadaver skin model requires comparison to clinical data, the current gold standard • Generic formulations of tretinoin gel 0.01% and 0.025% (Spear Pharm.) shown to be BE to Retin-A Gel 0.01% and 0.025% following clinical testing. • Will the cadaver skin model reach the same conclusion?

  4. DermPharm

  5. DermPharm

  6. DermPharm

More Related