Aurora Kinase Signaling Pathway

1. Aurora Kinase Signaling Pathway Aurora kinase is an important class of serine/threonine kinases responsible for the regulation of cell mitosis. In different model organisms, the structural and functional parts of members of the Aurora kinase family are highly conserved. In recent years, with the deepening of research on Aurora kinase, people have gradually recognized the important functions of Aurora kinase in cell mitosis and tumor formation. In cell mitosis, Aurora kinases are involved in many events such as centrosome maturation, spindle assembly and maintenance, chromosome segregation, and cytokinesis. Abnormally expressed aurora kinases tend to cause many abnormalities in the process of mitosis. In addition, Aurora kinase is involved in the process of tumor formation, and it has been found that some small molecules that target the aurora kinases have significant anti-cancer effects. Aurora kinase family Aurora kinase was first discovered in Drosophila mutants and was named for its abnormal spindle morphology like the Northern Lights. The human genome contains three aurora kinase members: aurora a, aurora b, and aurora c. These three homologous aurora kinases contain a conserved C-terminal catalytic domain and an N-terminal domain of varying lengths, all of which have different localization and function during mitosis. The aurora a gene is located on chromosome 20q13. From the S phase of the cell to the end of mitosis, Aurora A is localized to the centrosome. In addition, Aurora A is also distributed on the spindle microtubes. Aurora A plays an important role in mitosis. It regulates centrosome separation by phosphorylation of Eg5 in the early and middle stages. Deletion of Aurora-A or inhibition of its activity can cause centrosome separation failure, which ultimately leads to the appearance of a monopolar spindle. The maturation of the centrosome relies on centrosomin, NDEL1, T cell activation-associated protein (LAT), and transcription-associated acid coiled protein (TACC), which regulates the localization and function of these proteins. Find more at: https://www.creative-diagnostics.com/aurora-kinase-signaling-pathway.htm