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Awesome Presentation for the masses

This project aims to develop algorithms, methods, and tools for reagents, materials, and cell products in a closed-loop cell manufacturing platform. It includes downstream processing, upstream processing, culture substrate parameters, release testing, delivery, and formulation and filling.

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Awesome Presentation for the masses

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  1. Awesome Presentation for the masses Testing sub header

  2. ProjectOverview • Must include how the Project Aims and deliverables are explicitly driven by the engineered system’s requirements.   • Include the systems diagram that included in your 6 month report

  3. Project 2, Thrust 3, TB = All (Wang, White, Levine, Ashton, Saha, Roy, Levine) Development of novel supply chain and process modeling algorithms, methods, and tools for reagents, materials, and cell products Downstream Processing Cryopreservation, storage, release, transportation, delivery Cross-cutting Engineered System Closed-loop cell manufacturing platform with integrated, real-time analytics, potency measurement, and feedback process control Upstream Processing Project 3, Thrust 3, TB = MSC (Temenoff, Murphy, Galipeau, Karumbiah, Guldberg) Harvesting, pooling, separation and enrichment Cell transduction, gene-modification, genome editing Cell expansion and/or differentiation Effects of culture substrate parameters on MSC secretome Release testing, delivery and administration Project 4, Thrust 2, TB = T cells, All (Sulchek, Zhang, Sitaraman) Initial culture for purification, and selection Source cells, materials, and reagents Project 1, Thrust 3, TB = T Cell / iPSC (Ashton, Kamp, Levine, Brockbank) Formulation and filling Project 1, Thrust 1, TB = T Cells (Edison, Roy, Fernandez, Saha, Levine, Kotancheck, Torres-Garcia) Project 3, Thrust 1, TB = All (Kemp, Fernandez, McDevitt, Palecek, Mortensen) Project 5, Thrust 2, TB = MSC and T Cells (Ong, Guldberg, Roy, Temenoff) Project 1, Thrust 2, TB = T Cells (Saha, Roy, Karumbiah, Torres-logo) Joint Project, Thrust 2 and 3, TB = iPSC-CM (Palecek, Domenech, Kamp, Kane. McDevitt, Torres-Lugo, De la Fuente) Analysis of cryopreservation’s effect on cell isolates and manufactured therapeutic phenotypes Project 3, Thrust 2, TB = MSC (Garcia, Lam, Mortensen) Project 2, Thrust 2, TB = All (Fedorov, Resto, Guldberg) Development of real-time microfluidic and flexible electronics biosensors for monitoring cell and culture attributes during manufacturing Variability assessment and omics characterization of CAR-T cells through an integrative computational pipeline Tissue-on-a-chip platform for mesenchymal Stem Cell Potency Dynamic sampling platform (DSP) for cell state analysis and bioreactor monitoring Integration of imaging modalities with omics characterization Predictive CAR-T Potency assay for solid tumors using tumor-on-a-chip models Improving the quality of iPSC-derived cardiomyocytes by providing intercellular cues during scalable manufacturing Magnetoelastic microcarriers for real-time tracking of cell loading Project 2, Thrust 1, TB = MSC (Stice, Kemp, Platt, Edison, Fernandez) Exosome protein and cell surface signature: a critical quality attribute for MSCs

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