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Typhoid Fever

Typhoid Fever. Vincent Klokman. Classic Symptoms Slow, Progressive Fever Profuse sweating Gastroenteritis. Centers for Disease Control Public Heath Image Library. Typhoid Fever is caused By the Bacterium Salmonella typhi.

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Typhoid Fever

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  1. Typhoid Fever Vincent Klokman

  2. Classic Symptoms • Slow, Progressive Fever • Profuse sweating • Gastroenteritis Centers for Disease Control Public Heath Image Library

  3. Typhoid Fever is caused By the Bacterium Salmonella typhi

  4. Salmonella typhi is a motile, gram-negative facultative anaerobe.

  5. A Fecal-Oral Route of Transmission Spreads Typhoid Fever

  6. Asymptomatic Carriage Can Spread Typhoid Fever to Many People

  7. Salmonella Virulence due to: • Invasiveness • Intracellular survival & multiplication • Endotoxin • Cytotoxins FoodPoisonJournal.com Cred. Drew Falkenstein

  8. Siderophores Virulence Factors and Toxins Enterotoxin (diarrhea) Type 1 fimbriae (adherence) Endotoxin in LPS layer (fever) Virulence plasmid Cytotoxin Vi capsule antigen H antigen Brock: Figure 28.17 O antigen

  9. World Distribution of Typhoid Fever is largely in Developing Nations WHO

  10. With prompt antibiotic therapy, more than 99% of the people with typhoid fever are cured.

  11. Oral and Injectable Vaccines Are Available

  12. Virulence plasmid Vi capsule antigen; Inhibits complement binding Brock: Figure 28.17

  13. The Typhoid Vaccine is not Very Effective Klugman, K. "Protective Activity Of ViCapsularPolysaccharide Vaccine AgainstTyphoid Fever." The Lancet 330.8569 (1987): 1165-169. Print.

  14. and hand reduce several Typhoid Fever Simple Hygiene Washing can Instances of

  15. References • A.D.A.M. Medical Encyclopedia [Internet]. Atlanta (GA): A.D.A.M., Inc.; c1997-2012. Typhoid Fever; [last reviewed 2011 Jun 9; cited 2012 Mar 6]. Available from: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002308/ • Brock Biology of Microorganisms. San Francisco (Calif.): Pearson Benjamin Cummings, 2009. Print. • Klugman, K. "Protective Activity Of ViCapsularPolysaccharide Vaccine AgainstTyphoid Fever." The Lancet 330.8569 (1987): 1165-169. Print. • Merck Manual • Taber’s Medical Encyclopedia • CDC • WHO • Fraser A, Goldberg E, Acosta CJ, Paul M, Leibovici L (2007). "Vaccines for preventing typhoid fever". Cochrane Database Syst Rev (3): CD001261.

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