tiger-cunningham
Uploaded by
2 SLIDES
161 VUES
20LIKES

Correlation of CD3+ CD25 High and Low Ratios in Pre-Transplant Patients

DESCRIPTION

This study investigates the correlation among pre-transplant CD3+CD25high/CD3+HLA-DR+ and CD3+CD25low/CD3+HLA-DR+ ratios measured in blood samples from patients. Using FACS analysis, we examined triple-labelled samples with anti-CD25, anti-HLA-DR, and anti-CD3 markers. Results show distinct patterns in rejecting versus non-rejecting patient groups, highlighting significant correlations (R values) between the analyzed parameters. The implications of these correlations on transplant outcomes are discussed, with additional details provided in supplemental digital content.

1 / 2

Télécharger la présentation

Correlation of CD3+ CD25 High and Low Ratios in Pre-Transplant Patients

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. 6 P=ns P=ns 5 4 3 2 1 0 0 10 20 30 40 50 Early rejectors Non rejectors A B C R=-0.21 P= 0.06 P=ns CD3+CD25high CD3+CD25high CD3+CD25high CD3+HLA-DR+ CD3+HLA-DR+ CD3+HLA-DR+ D E F 60 R=-0.48 P=0.0001 R=-0.45 P=0.0001 R=-0.53 P=0.019 P=ns 50 40 CD3+CD25low CD3+CD25low CD3+CD25low 30 20 10 0 0 10 20 30 40 50 CD3+HLA-DR+ CD3+HLA-DR+ CD3+HLA-DR+ Supplemental Digital Content 2- Figure 2

  2. Correlation among pre-transplant CD3+CD25high/CD3+HLA-DR+ and CD3+CD25low/CD3+HLA-DR+ ratios. Pre-transplant blood samples were triple-labelled with anti-CD25PE, anti-HLA-DRFITC, and anti-CD3PerCP and analysed by FACS (Material and Methods). Values represent the measured percentages of CD25high, CD25low, and HLA-DR+cellson CD3+ cells. Shown are the results for the entire population of patients (A and D), plus the segregated results for the groups of rejecting (B and E) and non-rejecting (C and F) patients, where each dot corresponds to a single patient. The regression line between variables is shown. Pearson correlation coefficients (R) and (P) are indicated only when statistically significant. Center lines in B, C, E and F indicate the arbitrary threshold at 0.7% of CD3+ cells.

More Related