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  1. Supplemental Digital Content 3 - Figure 2. Trajectories of median CD4+ T-cell count in the 10 years after initiation of highly active antiretroviral therapy (HAART), according to CD4+ T-cell count levels before HAART initiation for 314 HIV-positive men who used HAART for at least 10 years (black lines) and for the 614 HIV-positive men who used HAART for at least 5 years (blue lines). The dots are median CD4+ T-cell count in each time interval from HAART initiation. Horizontal dotted lines are reference lines plotted at the CD4+ T-cell count of 200, 350, 500 cells/µl. The middle vertical dotted line shows the cutoff at five years after HAART initiation. The numbers below the labels of the x-axis are the percentages of undetectable HIV-1 RNA and total number of men in each time interval for the 314 men.