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Topology of Organometallic Radicals

Topology of Organometallic Radicals. How does coordination with transition metals affect reactivity&stereoelectronic parameters of propargyl cation&radical?. Alternative Strategies for Generation of Co2(CO)6 - Complexed Propargyl Radicals.

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Topology of Organometallic Radicals

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  1. Topology of Organometallic Radicals

  2. How does coordination with transition metals affect reactivity&stereoelectronic parameters of propargyl cation&radical?

  3. Alternative Strategies for Generation of Co2(CO)6 - Complexed Propargyl Radicals

  4. Tetrahydrofuran-Mediated Generation and Stereoselective Coupling of Cobalt-Complexed Propargyl Radicals

  5. THF: Synthetic Profile

  6. Understanding THF-Mediated Radical Reaction:Hydride Ion Transfer versus Direct Single Electron Reduction

  7. Mechanism of THF-Mediated Radical Reaction

  8. Unorthodox Radical Chemistry

  9. Spontaneous Generation of Cobalt- Complexed Propargyl Radicals

  10. Tentative Mechanism of Spontaneous Reaction

  11. The Effect of Temperature Upon Reaction Rate Gagik G. Melikyan, Boghos Mikailian, Ruth Sepanian, Pogban Toure. High-Temperature Reaction of a Co2(CO)6-Complexed Propargyl Cation. J. Organomet. Chem. 2009, 694,785-794.

  12. Temperature Time Yield d,l:meso de 20°C 11h 80.0% 94:6 88% 40°C 100min 93.0% 94:6 88% 83°C 6min 88.0% 92:8 84% 147°C 1min 84.0% 90:10 80% Yield and d,l-Diastereoselectivity NOT Compromised

  13. High Temperature Reactions in Cobalt-Alkyne Chemistry

  14. One-Step, Tf2O-Mediated Radical Reaction

  15. Generation of Cobalt-Complexed Propargyl Cations under Acidic Conditions

  16. Generation of Cobalt-Complexed Propargyl Cations under Acidic Conditions: An Alternative Approach

  17. Generation of Cobalt-Complexed Propargyl Cations under Neutral Conditions

  18. Expanding Reagent Base: Trifluoroacetic Anhydride vs Triflic Anhydride

  19. Expanding Substrate Base of Spontaneous Radical Reaction

  20. Can the New Method for Cation Generation Handle Acid-Sensitive Moieties?

  21. How Free the Cobalt-Complexed Radicals Are?

  22. New Avenue: Cross-Coupling Radical Reactions

  23. Charge distribution and structural parameters derived from the PM3 and 3-21G* calculation.

  24. Synopsis of Cross-Coupling Radical Reactions

  25. Intramolecular Cyclizations: Topology

  26. Intramolecular Radical Cyclizations: an Easy Access to 1,5-Cyclodecadiynes

  27. Diastereoselectivity of Intramolecular Cyclizations

  28. CH/pi-Coordination Leading to meso-Diastereomer

  29. X-Ray Structures of 1,5-Alkadiynes & 1,5-Cycloalkadiynes

  30. Synthetic Potential

  31. Functional Group Tolerance

  32. The Concept of Controlling the Concentration of Female Hormones

  33. Can Radical Dimers Compete with Testosterone for an Enzymatic Site?

  34. Aromatase Inhibitors (AIs): What is on the Market?

  35. DNA Cleaving Agents of New Topology

  36. Melikyan Research Group Spring 2009

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