High level of low density lipoprotein cholesterol in adult children of patients

1. Background High level of low density lipoprotein cholesterol (LDL-C) can bea critical contributor to elevated risk of coronary events in children of patientswith premature coronary heart disease (CHD) Material We examined members of 179 families. There were 171 parents-probands (65.2% men, 72.9% after MI) aged 40-63 years, their 113 consorts (24.1% men, 6.57% with CHD) aged 37-67 years and 215 probands children(50.7% men) aged 18-37 years without overt vascular disease. MethodsBody mass index (BMI) was calculated as follows: body mass (kg)/height (m2). Low density lipoprotein cholesterol was calculated with Friedwald‘s formula. High BP was defined as arterial prehypertension or hypertension (JNC-7 criteria). For diagnosis impaired glucose intolerance (IGT) and diabetes mellitus (DM) was used oral glucose tolerance test (WHO criteria). Before logistical regression for reduction of continuous coronary risk factors variabilityand to suppress possible outliers the symmetric censoring of 1% of their values was carried out. High LDL-C was defined as 3.36 mmol/l, its predictors were selectedby binary logistical regression analysis with adjustment for age and sex. Purpose To elucidate associations between high LDL-C in adult childrenof patients with premature (onset <55 years, men; <60 years, women) CHDand their own and parental characteristics. Parameters registeredalcohol consumption, tobacco smoking,, oral contraceptive use, height, body mass index (BMI), waist circumference (WC), heart rate,systolic and diastolic blood pressure (BP), totaland high density lipoprotein cholesterol, LDL-C, triglycerides, basal serum glucose, impaired glucose tolerance, diabetes mellitus (ADA criteria),arterial prehypertension and hypertension, metabolic syndrome (MS, IDF criteria), use triglyceride and LDL-C lowering drugs and (in parents) education level and presence of menstruation. Results Adult children *Criterion of high LDL-C = ≥3.36 mmol/l (130 mg/dl) with LDL-C ≥3.36 mmol/l (41/84 [48.8% men])– 84/215 (39.1%) with LDL-C <3.36 mmol/l (68/131 [51.9% men])– 131/215 (60.9%) 39.1% *cut point was taken arbitrarily 60.9% High level of low density lipoprotein cholesterol in adult children of patients with premature coronary heart disease: relation to own and parental characteristics MV. Konnov, LM. Dobordzhginidze, AD. Deev, NA. GratsianskyCenter for Atherosclerosis, Institute Of Physico-Chemical Medicine, Moscow, Russian Federation Table 1. Results of univariate analysis Table 2. Results of multivariate analysis Conclusions • In this group of adult children with parental premature CHD: • LDL-C level of proband-parent was independently associated with high LDL-C; • However characteristics of consort-parent (LDL-C and BMI) were also independently related to high LDL-C in their adult children. For further information or comments: konnov-mihail@yandex.ru