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PTEN

PTEN. Multifunctional Tumor Suppressor. PTEN c rystal structure contains a phosphatase and C2 domain. Lumb , C. N., & Sansom , M. S. (2013). Defining the Membrane-Associated State of the PTEN Tumor Suppressor Protein.  Biophysical Journal ,  104 (3), 613-621.

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PTEN

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  1. PTEN Multifunctional Tumor Suppressor

  2. PTEN crystal structure contains a phosphatase and C2 domain Lumb, C. N., & Sansom, M. S. (2013). Defining the Membrane-Associated State of the PTEN Tumor Suppressor Protein. Biophysical Journal, 104(3), 613-621.

  3. PTEN binds PIP3, a phospholipid substrate Lumb, C. N., & Sansom, M. S. (2013). Defining the Membrane-Associated State of the PTEN Tumor Suppressor Protein. Biophysical Journal, 104(3), 613-621.

  4. PTEN opposes PI3 Kinase to keep PIP3 levels low • J.ClinOncol. July 15, 2004 vol. 22 no. 14 2954-2963. DOI: 10.1200/JCO.2004.02.141

  5. PTEN regulates the AKT pathway which has multiple biological roles Backman, S., Stambolic, V., & Mak, T. (2002). PTEN function in mammalian cell size regulation. Current opinion in neurobiology, 12(5), 516.

  6. Mice PTEN null ES cells grow excessively with disorganized patterning Cristofano, A. D., Pesce, B., Cordon-Cardo, C., & Pandolfi, P. P. (1998). Pten is essential for embryonic development and tumour suppression. Nature genetics, 19(4), 348-355.

  7. Cancers with PTEN mutations occur in a dosage dependent manner Cristofano, A. D., Pesce, B., Cordon-Cardo, C., & Pandolfi, P. P. (1998). Pten is essential for embryonic development and tumour suppression. Nature genetics, 19(4), 348-355. http://www.nature.com/ng/journal/v42/n5/images_article/ng.556-F3.jpg

  8. PTEN is one of the most frequently mutated genes in human cancers Eng, C. (2003). PTEN: one gene, many syndromes. Human mutation, 22(3), 183-198.

  9. Cowden Syndrome : hamartomas, benign tumorsdue to germline mutations often in PTEN phosphatase catalytic site http://www.hinsdale86.org/staff/kgabric/Disease10/Cowden%20Syndrome/Index1.htm

  10. Cowden Syndrome patients display an increased predisposition for cancer

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