1 / 21

Research Opportunities in the Department of Otolaryngology-Head and Neck Surgery

Research Opportunities in the Department of Otolaryngology-Head and Neck Surgery. Kibwei A. McKinney, MD Yu-Tung Wong, MD Scott Shadfar , MD. Outline. Funding opportunities Subspecialty Areas Clinical/Research Faculty Areas of Interest Examples. ENT Residency Application.

uyen
Télécharger la présentation

Research Opportunities in the Department of Otolaryngology-Head and Neck Surgery

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Research Opportunities in the Department of Otolaryngology-Head and Neck Surgery Kibwei A. McKinney, MD Yu-Tung Wong, MD Scott Shadfar, MD

  2. Outline • Funding opportunities • Subspecialty Areas • Clinical/Research Faculty • Areas of Interest • Examples

  3. ENT Residency Application • Step 1 USMLE Score • Medical School GPA • Extra-curricular Activities • Research

  4. Duration of Research • 2 months – Projects completed during the summerin between the 1st and 2nd yr • 1 year – Projects completed during a year off in between the 3rd and 4th years of medical school

  5. Grants/Funding Opportunities • 2 months – Research Training in Otolaryngology Program (8-12 weeks) • Application online at Carolina Medical Student Research Program website: www.med.unc.edu/rschofc/omsr/cmsrp.htm • Due Feb. 8th, 2010 • 1 year - https://cgibd.med.unc.edu/omsr/oppor.php • Research Training in Otolaryngology • Doris Duke Clinical Fellowship Program • American Otologic Society Research Fellowship (T32) • Howard Hughes Medical Institute Training Fellowship • Holderness Fellowship (4 Yearly)

  6. Otolaryngology Subspecialty Areas • Head and Neck Surgery (Cancer Research) • Otology/Neurotology • Facial Plastic Surgery • Rhinology/Sinus Surgery • Laryngology • Anterior Skull Base Surgery • Pediatric Otolaryngology

  7. Head and Neck Surgery • Marion Couch, MD, Ph. D. – Cancer Cachexia • Neil Hayes, MD, MPH – Molecular pathogenesis of head and neck Cancers • Mark Weissler, MD – Outcomes Research in Head and Neck Cancer • Carol Shores, MD – EBV related Head and Neck Cancer in Lilongwe, Malawi

  8. Cancer Cachexia • Loss of weight, muscle atrophy, catabolism associated with end-stage cancer • Significant cause of morbidity

  9. Cancer Cachexia • Historically thought to be mediated by increased energy expenditure by rapidly proliferating cancer cells • Increasing body of evidence attributing cachexia to pathophysiologic mechanisms at the cellular level • NF-κB – ubiquitous protein complex that controls DNA replication • When constitutively active, proper regulation does not occurcellularproliferationtumor • AlsoInflammation (possibly leading to cachexia)

  10. Resveratrol • Potential NF-κB Inhibitor • Natural compound found in red wine, red grapes • Increased life span of nematode and short-lived fish • If good enough for the nematode, why not for us?

  11. Putting Resveratrol to the Test Day 0 –Tumor Inoculation Days 1-17 Document Cachexia/Treat with Resveratrol Sacrifice and Harvest

  12. Outcomes • Tumor size • Body weight • Tissue NFκB levels • Cardiac echo readings

  13. Otology/Neurotology • Doug Fitzpatrick, Ph. D. – Preservation of residual hearing in cochlear implantation • Paul Manis, Ph. D. – Cellular mechanisms/neural networks of hearing • John Grose, Ph. D. – Age-Related decline in temporal processing • Craig Buchman, MD – Auditory Neuropathy, CI Outcomes • Oliver Adunka, MD – Electroacoustic Stimulation (EAS); Intraoperative electrophysiology • Joe Hall Ph. D./Emily Buss – Psychoacoustics • Joseph Roche, MD – SNHL and synaptic plasticity in Te1 Vestibulocochlear system of the Mongolian Gerbil; animal model used in electroacoustic studies

  14. Facial Plastic and Reconstructive Surgery • William Shockley, MD • Interests: Microtia repair, nasal defects and rhinoplasty, congenital anomalies • Clinical Outcomes Research

  15. Rhinology/Sinus Surgery • Julia Kimbel, Ph. D. – computational fluid dynamics, particle uptake deposition • Brent Senior, MD – MIPS Outcomes Research, Sleep Research • Charles Ebert, MD – QOL Outcomes for sinus surgery, Allergic Fungal Rhinosinusitis

  16. Allergic Fungal Rhinosinusitis • Disease process characterized by fungal proliferation, inflammation and deformation of the normal bony anatomy • Presents unilaterally in over 40% of patients • Hypothesis: These patients represent a genetic chimera with differential expression on the contralateral sides of the nose • Microarray analysis will be used to characterize these differences

  17. Laryngology • Robert Buckmire - Medical Robotic System for Laser Phonomicrosurgery • Joint venture with UNC/NC State Dept. of Biomedical Engineering • Image Guidance in Laryngeal Surgery

  18. Laryngeal Phonomicrosurgery • Group of Complex surgical techniques that leverage the use of endoscopic tools • Surgical laser (CO2) under the control of a micromanipulator • Problem: poor ergonomics

  19. Laryngeal Phonomicrosurgery • Hypotheses: • Different user interfaces may be advantageous in providing increased fine motor manipulation of the laser. • A trained robot may make more precise, uniform cuts than those made by a human

  20. Skull Base Surgery • Adam M. Zanation, MD – Molecular biology of sinonasal tumors, radioanatomic analysis of the pediatric skull base, outcomes research in endoscopic skull base surgery PPF PPF GPC GPC Mucosa Mucosa

  21. Pediatric Otolaryngology • Amelia Drake, MD • Austin Rose, MD • Carlton Zdanski, MD, FACS • Rose Payapilli, MD (resident) – clinical outcomes in patients with cochlear malformation after CI

More Related