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Analysis of Tumor Response to AI and Tamoxifen Therapy: Supplemental Figures Overview

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This document presents supplemental figures detailing the normalized intensity of tumor response to various treatments, particularly focusing on AI (aromatase inhibitor) and Tamoxifen (Tam). The data comprises pre- and post-treatment comparisons, including measures of positivity and tumor grade. Figures include assessments of response rates, status changes, and Ki-67 IHC evaluation post-treatment. The findings aim to provide insight into treatment efficacy and potential residual tumor presence after therapeutic interventions.

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Analysis of Tumor Response to AI and Tamoxifen Therapy: Supplemental Figures Overview

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  1. Supplemental Figure 1 78 78 74 74 70 70 66 66 62 62 58 58 54 54 50 50 Normalized Intensity 46 46 42 42 38 38 34 34 #4 – NR (AI+Tam) #7 – NR (AI only) 30 30 #9 – NR (AI+Tam) 26 26 #11 – NR (AI+Tam) 100 #14 – NR (AI+Tam) 22 22 #1 – R (AI only) 18 18 #2 – R (AI only) 75 #5 – R (AI only) 14 14 #6 – R (AI only) 10 10 #8 – R (AI only) % Positive 50 6 6 #13 – R (AI only) #16 – R (AI only) 2 2 #17 – R (AI only) Pre Post Pre Post 25 #18 – R (AI only) #19 – R (AI only) NR R 0 A. B. R NR NR R Pre Post C. dropped out no residual tumor Pre Post Pre Post NR R

  2. #4 – NR (AI+Tam) #7 – NR (AI only) #9 – NR (AI+Tam) #11 – NR (AI+Tam) #14 – NR (AI+Tam) #1 – R (AI only) #2 – R (AI only) #5 – R (AI only) #6 – R (AI only) #8 – R (AI only) #13 – R (AI only) #16 – R (AI only) #17 – R (AI only) #18 – R (AI only) #19 – R (AI only) Supplemental Figure 2 PR IHC 100 dropped out 75 % Positive 50 25 0 Pre Post Pre Post NR R

  3. PHT Ki 67 IHC Tumor Grade #4 – NR (AI+Tam) 100 3.0 #7 – NR (AI only) #9 – NR (AI+Tam) #11 – NR (AI+Tam) #14 – NR (AI+Tam) 75 2.5 #1 – R (AI only) #2 – R (AI only) #5 – R (AI only) #6 – R (AI only) 2.0 50 #8 – R (AI only) #13 – R (AI only) #16 – R (AI only) 1.5 25 #17 – R (AI only) #18 – R (AI only) #19 – R (AI only) 1.0 0 Pre Post Pre Post Pre Post Pre Post NR R NR R Supplemental Figure 3 Grade % Positive

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