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Analysis of Tumor Response to AI and Tamoxifen Therapy: Supplemental Figures Overview

This document presents supplemental figures detailing the normalized intensity of tumor response to various treatments, particularly focusing on AI (aromatase inhibitor) and Tamoxifen (Tam). The data comprises pre- and post-treatment comparisons, including measures of positivity and tumor grade. Figures include assessments of response rates, status changes, and Ki-67 IHC evaluation post-treatment. The findings aim to provide insight into treatment efficacy and potential residual tumor presence after therapeutic interventions.

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Analysis of Tumor Response to AI and Tamoxifen Therapy: Supplemental Figures Overview

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  1. Supplemental Figure 1 78 78 74 74 70 70 66 66 62 62 58 58 54 54 50 50 Normalized Intensity 46 46 42 42 38 38 34 34 #4 – NR (AI+Tam) #7 – NR (AI only) 30 30 #9 – NR (AI+Tam) 26 26 #11 – NR (AI+Tam) 100 #14 – NR (AI+Tam) 22 22 #1 – R (AI only) 18 18 #2 – R (AI only) 75 #5 – R (AI only) 14 14 #6 – R (AI only) 10 10 #8 – R (AI only) % Positive 50 6 6 #13 – R (AI only) #16 – R (AI only) 2 2 #17 – R (AI only) Pre Post Pre Post 25 #18 – R (AI only) #19 – R (AI only) NR R 0 A. B. R NR NR R Pre Post C. dropped out no residual tumor Pre Post Pre Post NR R

  2. #4 – NR (AI+Tam) #7 – NR (AI only) #9 – NR (AI+Tam) #11 – NR (AI+Tam) #14 – NR (AI+Tam) #1 – R (AI only) #2 – R (AI only) #5 – R (AI only) #6 – R (AI only) #8 – R (AI only) #13 – R (AI only) #16 – R (AI only) #17 – R (AI only) #18 – R (AI only) #19 – R (AI only) Supplemental Figure 2 PR IHC 100 dropped out 75 % Positive 50 25 0 Pre Post Pre Post NR R

  3. PHT Ki 67 IHC Tumor Grade #4 – NR (AI+Tam) 100 3.0 #7 – NR (AI only) #9 – NR (AI+Tam) #11 – NR (AI+Tam) #14 – NR (AI+Tam) 75 2.5 #1 – R (AI only) #2 – R (AI only) #5 – R (AI only) #6 – R (AI only) 2.0 50 #8 – R (AI only) #13 – R (AI only) #16 – R (AI only) 1.5 25 #17 – R (AI only) #18 – R (AI only) #19 – R (AI only) 1.0 0 Pre Post Pre Post Pre Post Pre Post NR R NR R Supplemental Figure 3 Grade % Positive

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