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Training to Improve Survival Initiative

Training to Improve Survival Initiative

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Training to Improve Survival Initiative

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  1. Training to Improve Survival Initiative “THE WAR ON PANCREATIC CANCER REQUIRES DEDICATION” Sinjan bose April 23, 2012

  2. Facts about Pancreatic Cancer 4th leading cause of death Only one with a 5 year survival rate of 6% Survival rate has not improved since passage of National Cancer Act of 1971 In 2012, 43,920 Americans will be diagnosed and 37,390 will die 75% of patients die within the first 12 months of diagnosis Only 2% of NCI’s annual budget allocated

  3. 2012 Relative Five Year Survival Rates

  4. NCI Annual Funding 2001-2010

  5. Issues Lack of funding towards research Physician and public awareness of the disease Future supply of scientists in serious jeopardy

  6. Pancreatic Research and Education Act Develop a Strategic Plan for Research Cancer Research Incubator Pilot for the Deadly Cancers Strengthening and Expanding SPORE for Pancreatic Center Promoting Physician and Public Awareness

  7. Strategic Plan for Research • Amend Part B of title III of Public Health Service Act (42 U.S.C. 243 et. seq.) • § 320B(a). Pancreatic Cancer Initiative. “The Secretary shall establish and implement a Pancreatic Cancer Initiative to assist in coordinating activities to address the high mortality rate associated with pancreatic cancer. Such initiative shall focus on: • (A) advancing research on the causes, diagnosis, and treatment of pancreatic cancer with the goal of increasing 5-year survival”

  8. Strategic Plan for Research • Amend Part B of title III of Public Health Service Act (42 U.S.C. 243 et. seq.) • § 320B(b). Interdisciplinary Pancreatic Cancer Coordinating Committee. • (1) Establishment • (2) Membership • (3) Responsibilities • (4) Strategic Plan • “(A) Development – The Committee shall develop not later than 6 months of the Committee’s establishment and update not less than every 5 years thereafter a strategic plan for the conduct and support of pancreatic cancer research and awareness for the upcoming fiscal 5-year period”

  9. Strategic Plan for Research • Amend Part B of title III of Public Health Service Act (42 U.S.C. 243 et. seq.) • § 320B(b). Interdisciplinary Pancreatic Cancer Coordinating Committee. • (1) Establishment • (2) Membership • (3) Responsibilities • (4) Strategic Plan • (5) Prioritization and Award of NIH Research Grants • In General. – The Committee shall conduct evaluations and make recommendations as needed to the Secretary, the Director of National Institutes of Health, and the Director of the National Cancer Institute regarding prioritization and award of NIH research grants relating to pancreatic cancer

  10. Cancer Research Incubator Pilot for the Deadly Cancers • Amend Part B of title IV of Public Health Service Act (42 U.S.C. 284 et. seq.) • § 409K. Cancer Research • (a) Cancer Research Incubator Pilot Project – • (1) Grants – • (A) In General – The Secretary may award grants to research institutions for use in developing innovative compounds or technologies for the prevention, early detection, or treatment of those cancers with 5-year survival rates of less than 50%

  11. Strengthening and Expanding of Excellence for Pancreatic Center • Amend Part B of title IV of Public Health Service Act (42 U.S.C. 284 et. seq.) • § 409K. Cancer Research • (b) Centers of Excellence – • (1) Designation – The Secretary may designate two additional Specialized Programs of Research Excellence (SPOREs) focusing solely on pancreatic cancer research. In carrying out this paragraph, the Secretary may choose to designate 1 or more satellite centers that augment the work of a previously designated Specialized Program of Research Excellence

  12. Promoting Physician and Public Awareness • Amend Part B of title III of Public Health Service Act (42 U.S.C. 243 et. seq.) • § 320B(c). Physician Awareness • (1) Program. – The Secretary, in consultation with the Director of the National Institutes of Health, the Director of the Centers for Disease Control and Prevention, and relevant patient advocate and physician organizations, shall develop a primary care provider education program on pancreatic cancer. The Secretary may include in such program accredited continuing medical education and such other activities as the Secretary determines appropriate

  13. The NCI and Pancreatic Cancer Allocates budget through grant mechanisms – R grants From 2008 to 2009 number of R grants increased from 216 to 231 but amount of grants decreased from $49.1 million to $48 million Fellowship, Career, and Training Awards (FKT) decreased by 15% from 2008 to 2009

  14. The NCI and Pancreatic Cancer

  15. Training to Improve Survival Initiative • Amend § 320B. Pancreatic Cancer Initiative • Add (a)(4)(C)(iv). • “The grant will develop education and training resources for investigators and health care providers about pancreatic cancer risk assessment, evaluation protocols, and sample collection.”

  16. Policy Paramours • U.S. Senate • Sheldon Whitehouse (D-RI) • Tom Harkin (D-IA) • U.S. House of Representatives • Anna Eshoo (D-CA) • Leonard Lance (R-NJ) • Dave Reichert (R-WA) • Tim Murphy (R-PA) • Republican Physician’s Caucus Co

  17. Opposition • U.S. House of Representatives • Fred Upton (R-MI) • Ed Whitefield (R-KY) • Steve Scalise (R-LA)

  18. Stakeholders • Governmental • Center for Medicare and Medicaid Services • Center for Disease Control and Prevention • Department of Health and Human Services • National Institutes for Health • National Cancer Institute • Food and Drug Administration • Non-governmental • Pancreatic Cancer Action Network (PANCAN) • Cancer Leadership Council • American Association of Cancer Research (AACR) • American Pancreatic Association • Doctors, Caregivers, Scientists • Major Hospitals

  19. References American Cancer Society. Cancer Facts & Figures 2012. Atlanta: American Cancer Society; 2012 Surveillance, Epidemiology, and End Results (SEER) Program, National Cancer Institute. “Age-Adjusted U.S. Death Rates and Trends for the Top 15 Cancer Sitesa by Race/Ethnicity, Both Sexes” Smith BD, Smith GL, Hurria A, Hortobagyi GN, Buchholz TA. Future of Cancer Incidence in the United States: Burdens Upon an Aging, Changing Nation. J ClinOncol. 2009 Li D, Xie K, Wolff R, Abbruzzese JL. Pancreatic Cancer. Lancet.2004; 363:1049 – 1057 Oettle H, Post S, Neuhaus P, et al. Adjuvant Chemotherapy With Gemcitabinevs Observation in Patients Undergoing Curative-Intent Resection of Pancreatic Cancer: A Randomized Controlled Trial. JAMA. 2007;297:267-277. American Cancer Society. www.pancan.org