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Nigel S. Lockyer, Director/Directeur

CANADA’S NATIONAL LABORATORY FOR PARTICLE AND NUCLEAR PHYSICS. Owned and operated as a joint venture by a consortium of Canadian universities via a contribution through the National Research Council Canada.

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Nigel S. Lockyer, Director/Directeur

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  1. CANADA’S NATIONAL LABORATORY FOR PARTICLE AND NUCLEAR PHYSICS Owned and operated as a joint venture by a consortium of Canadian universities via a contribution through the National Research Council Canada Une Vision pour la prochaine décennieatteindre les objectifs de recherche du Canada et paver le chemin de l’économie du savoir A Vision for the Next DecadeAchieving Canada’s Research Goals & Leading the Knowledge-Based Economy Nigel S. Lockyer, Director/Directeur Superconducting Cavity 1st Made in Canada PET Radiotracer LABORATOIRE NATIONAL CANADIEN POUR LA RECHERCHE EN PHYSIQUE NUCLÉAIRE ET EN PHYSIQUE DES PARTICULES Propriété d’un consortium d’universités canadiennes, géré en co-entreprise à partir d’une contribution administrée par le Conseil national de recherches Canada

  2. Members Carleton University Simon Fraser University University of Alberta University of BC Université de Montréal University of Toronto University of Victoria Associate Members McMaster University Queen’s University* Saint Mary’s University University of Guelph* University of Manitoba* University of Regina York University* 99 Year lease Owned and Operated by a Consortium of 14 Universities 7 full members & 7 associate members 2

  3. Awards and Recognition TRIUMF team widely recognized for excellence • Ryu Hayano, Japan’s Nishina Memorial Prize 2008 • Jess Brewer, CAP Brockhouse Prize • Carl Svensson, NSERC Steacie Fellowship & CAP Herzberg • Dugan O’Neil, BC Innovation Council Young Innovator Prize • Mike Barnes, on location 3 years to commission LHC • Pierre Savard, Exotics Physics Group Leader, ATLAS • Two NSERC Synergy Awards (MDS Nordion, D-PACE) • Mark Martinez, BC Lieutenant Gov. Techn. Innovation Award • Igor Sekachev, US Nat’l Academies, helium shortage cttee • Tom Ruth, US Nat’l Academies, medical isotopes cttee(HEU) • Vesna Sossi, Michael Smith Foundation Fellowship • David Sinclair, Carleton U. Medal for Distinguished Research 4

  4. TRIUMF Attracts Top Talent to Canada • Lia Merminga, Head of Accelerator Division (USA) • Elected Chair ‘10 American Physical Society Beams Division • Vaishali Naik, VECC visiting accelerator scientist (India) • Cornelia Hoehr, nuclear medicine (Germany) • Oliver Stetzler, particle physics LHC (Germany) • Anadi Canepa, particle physics LHC (Italy) • ATLAS Canada graduate students • Currently 65 students, plan for ~100 • 1/3 on NSERC Fellowships • 1/3 international • 40% of students at TRIUMF are international 5

  5. Present Successes 6

  6. CERN TRIUMF CERN 2008 Excellence in Nuclear Science A New Era in Mass Measurements 11Li • Highest power Rare Isotope Beam (RIB) facility in world • Most intense beams of certain species in world • A dozen world-class experiments on floor • Supported by NSERC through peer-review process 7

  7. Astrophysics Highlights 2008/2009 • June 2008: 18F(p,p)18F and 18F(p,)15O at TUDA • Highest 18F intensity for this reaction so far • November 2008: First direct measurement of 23Mg(p,)24Al at DRAGON • December 2008: Implantation of 22Na targets at ISAC • December 2008: ISAC-II measurement of lifetime of 6.79 MeV state in 15O for 14N(p,)15O reaction rate determination • February 2009: 22Na(p,)23Mg using ISAC targets at University of Washington, Seattle • Details in presentations • 5-year plan has astrophysics prominent

  8. Leading Rare Isotope Facilities Global investment in RIBs over next decade ~$4B (OECD) 2008 Dec 8 9

  9. ATLAS Canada TRIUMF design built at Alstom Tracy Quebec Hadronic Endcap & Forward Calorimeter Total Investment by Canada ~$100M Delivered on time, on budget, working well 10

  10. Knowledge Transfer & Commercialization • TRIUMF bridges commercial and academic sectors • Research  Innovation  Commercialization • Partnership with MDS Nordion is model program for the world • Produces 2.5 million patient doses of medical isotopes per year • ~3000 patient doses of FDG to BCCA per year • More than 125 patients ocular melanoma with protons (BCCA) • NSERC Synergy Award 2003 • R&D partnership in value-added isotopes launched October 2008 • D-PACE (NSERC Synergy Award 2007) • TRIUMF-designed cyclotrons in use worldwide • Advanced Applied Physics Solutions (AAPS) Inc. • First-round Centre of Excellence Commercialization & Research (CECR) • $2.25M partnership with physics institute in India (signed Aug 2008) • Si-32 MOU with US for phytoplankton research (only source in NA) 11

  11. The 5-Year Plan 12

  12. 5-Year PlanBuilding on Opportunities • TRIUMF is poised for a transformation • Opportunities, skills, and past investments are coming together • Future plan seizes 3 new strategic opportunities • Platform technology: superconducting RF (SRF) • Accelerators, medical-isotope production, flue-gas scrubbing • Platform technology: nuclear medicine • Lead emerging revolution • Playing a major role in world’s largest scientific project: LHC • Canadian Physics Analysis Centre & Tier-1 Data Centre • Requested investments • $328M for 2010-2015 operations • $60M for capital infrastructure (buildings) 13

  13. Success: EF5-18F (a first in Canada) Tests for Hypoxia – radiation-resistant tumours 14

  14. Excellence in Nuclear Medicine • Program started in neurology, expanding to oncology • World leading Pacific Parkinson’s Research Centre (PPRC) (1500 patient visits a year) • Entire program depends on TRIUMF • Major discoveries: Placebo effect; Trauma origins • Core competencies • PET Imaging (synergy with $43M animal care facility—rabbit line) • Radiochemistry and biomarkers (18F, 11C….) • Target development techniques • “This entire field of application is predicated on radiotracer creation, radiopharmaceutical preparation, radiochemistry and interpretative radiobiology—all aspects established within the practical and intellectual domain of TRIUMF.” —Simon B. Sutcliffe, CEO BCCA 15

  15. Nuclear Medicine RevolutionDrives Personalized Medicine • “The level of knowledge and expertise within TRIUMF and MDS Nordion gives us a unique global competitive advantage…” • Steve West, President, MDS Nordion • Disease metabolism subject to detailed investigation with targeted labeled molecules --- amino acid transporters, peptides… etc • Establish cancer staging (metastasis) & efficacy of treatment with quick turn around (FDG PET) • Dr. Dan Worsley stated that the introduction of PET/CT scans at the BCCA resulted in changes to more than 50% of the treatments for scanned patients • Move towards imaging and therapy isotopes for cancer treatment (alpha emitters), e.g., 211At • Leads to mini SC cyclotron (espresso maker) in every hospital  AAPS 16

  16. UBC/TRIUMF (Lead) McMaster University Cross Cancer Institute MNI Ottawa Heart Institute Université de Sherbrooke BC Cancer Agency St Joseph's Health Care Sunnybrook Thunder Bay University Health Network (PMH) University of Calgary Dalhousie University University of Manitoba Université de Montréal Institutions Partnering w/TRIUMF Active Cyclotron Based Programs Establishing Cyclotron Programs Terry Fox Research Institute 17

  17. CECRs Partnering w/TRIUMF • Advanced Applied Physics Solutions, Inc. (AAPS), Vancouver, BC • Centre for Drug Research and Development (CDRD), Vancouver, BC • The Prostate Centre’s Translational Research Initiative for Accelerated Discovery and Development (PC-TRIADD), Vancouver, BC • Centre for Probe Development and Commercialization (CPDC), Hamilton, ON 18

  18. SRF at TRIUMF: past, present, future ISAC II Phase I 106 MHz β =0.057, 0.071 Ep=30 MV/m ISAC II Phase II 141 MHz β =0.11 Ep= 30 MV/m E-linac/VECC 1.3 GHz β = 1 Ep= 20 MV/m SPL 704 MHz β = 0.65, 1 Ep= 50 MV/m ILC 1.3 GHz β = 1 Ep= 63 MV/m TRIUMF is becoming a leading SRF science and technology center. 19

  19. World Leadership in RIBs • Goal of 5-yr plan – exploit SRF technologies for RIBS • Unique moment to seize scientific discovery opportunity • Study neutron-rich nuclei important for element abundances, supernova explosions, neutron-star crusts, shell structure, theory advances, universal nuclear density functional, 3-nucleon interactions,... • Great opportunity in fundamental symmetries (one of holy grails in nuclear physics) --- Prize winning science • TRIUMF has strong fleet of experiments & eager young researchers • Large international user base wanting and waiting for varied beams • Accelerator team strong & unique in Canada • Canada: Opportunity to lead on world nuclear physics stage 20

  20. Outlook 21

  21. & others NSERC: $35m CFI: $18m NRC: $328m Others: $48m BC: $60.7m one time Fast job creation: TRIUMF expansion to create a total of 179 person-years of construction work (inc. 71 FTE by 2010) Economic Impacts of TRIUMF & Proposed Expansion Estimated Impacts 2009 – 2014 • World-leading particle & nuclear physics research facility & program • Heart of a growing BC advanced tech cluster (MDS, BCCA, PAVAC, etc.) • Canada’s leader in global “big science” (CERN-LHC, T2K, CSUNS, etc.) • Research applications in technologies relevant to British Columbia: nuclear medicine, environment,natural resources, aerospace, electronics Five-year economic impacts: • $912 million total provincial output • $511 million total provincial GDP • 1,284 permanent FTE jobs • $50 million provincial tax revenues

  22. Vancouver, BC ±15 imaging staff Vancouver, BC ±90 employees Richmond, BC ±20 employees Richmond, BC ±20 employees Vancouver, BC ±475 employees Vancouver, BC ±5 employees Nelson, BC ±10 employees Particle Accelerator National & International & Nuclear Medicine Communities

  23. The 5-year plan is an opportunity for TRIUMF and the university community to position Canada as a lead nation in science & technology 24

  24. 4004 Wesbrook Mall Vancouver, B.C. Canada V6T 2A3 Tel: 604 222-1047 Fax: 604 222-1074www.triumf.ca Thank you Merci

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