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Discover Bioinformatics Secrets Through Beading with Dr. Toby Horn

Dive into the world of bioinformatics with Dr. Toby Horn. Learn how to model DNA sequences using beads, unearthing the secrets hidden within. Connect your models to real sequence data and explore the applications of bioinformatics, such as genome analysis and disease tracing. Join us to unravel the mysteries of biological systems! Dr. Toby M. Horn brings his expertise and passion for bioinformatics to guide you on this exciting journey.

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Discover Bioinformatics Secrets Through Beading with Dr. Toby Horn

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  1. Secrets’NSequences Begin by Beading Bioinformatics “Dr Toby” Horn Toby M Horn, PhD thorn@ciw.edu

  2. What we’ll do • About Bioinformatics • Model-building • Connecting your model to real sequence information • Extensions and teaching strategies Toby M Horn, PhD thorn@ciw.edu

  3. We dance round in a ring and suppose But the Secretsits in the middle and knows. The Secret Sits by Robert Frost Toby M Horn, PhD thorn@ciw.edu

  4. bioinformatics is … • the use of computer science, mathematics, and information theory to model and analyze biological systems. • the collection, organization and analysis of large amounts of biological data, using networks of computers and databases. • the use of computing tools to manage and analyze genomic and molecular biological data. Toby M Horn, PhD thorn@ciw.edu

  5. So What? Toby M Horn, PhD thorn@ciw.edu

  6. Applications of Bioinformatics • Understanding how our genomes work • Tracing the pathway of emerging diseases • Developing modified strains of crops with better quality and quantity of protein, vitamin, oil • And more Toby M Horn, PhD thorn@ciw.edu

  7. Model a DNA Sequence with Color-Coded Nucleotides A C T G Toby M Horn, PhD thorn@ciw.edu

  8. Source of Beads (and elastic findings) www.consumercrafts.com (acrylic faceted beads, 8mm) Toby M Horn, PhD thorn@ciw.edu

  9. Toby M Horn, PhD thorn@ciw.edu

  10. Toby M Horn, PhD thorn@ciw.edu

  11. Mnemonicshelp us rememberSo, we make color choices based on… • Sounds • Adenine-Red • Guanine-Gold • Cytosine-SkyBlue • School Colors (Ballou/McKinley) • Fashion Toby M Horn, PhD thorn@ciw.edu

  12. What You’ll Do • String 18 beads in a pattern (or not) that YOU like • Enter the sequence in GenBank • Discover the secret of your sequence Toby M Horn, PhD thorn@ciw.edu

  13. Stringing Your Beads You have a bracelet length of elastic. • Tie a double knot in one end, leaving about 3 cm. • Bead from the long end of the elastic. • Stretch the elastic just a little and tie a double-knot on the free end close to the beads (should leave about 3 cm or more). • Bead both ends through another bead. Double knot the ends together. Cut the longer piece of elastic. Toby M Horn, PhD thorn@ciw.edu

  14. Stringing Your Beads • Tie a double knot in one end, leaving about 3 cm. • Bead from the long end of the elastic. • Stretch the elastic just a little and tie a double-knot on the free end close to the beads (should leave about 3 cm or more). • Bead both ends through another bead. Double knot the ends together. Cut the longer piece of elastic. Toby M Horn, PhD thorn@ciw.edu

  15. Stringing Your Beads • Tie a double knot in one end, laving about 3 cm. • Bead from the long end of the elastic. • Stretch the elastic just a little and tie a double-knot on the free end close to the beads (should leave about 3 cm or more). • Bead both ends through another bead. Double knot the ends together. Cut the longer piece of elastic. Toby M Horn, PhD thorn@ciw.edu

  16. Stringing Your Beads • Tie a double knot in one end, leaving about 3 cm. • Bead from the long end of the elastic. • Stretch the elastic just a little and tie a double-knot on the free end close to the beads (should leave about 3 cm or more). • Bead both ends through another bead. Double knot the ends together. Cut the longer piece of elastic. Toby M Horn, PhD thorn@ciw.edu

  17. Stringing Your Beads • Tie a double knot in one end, leaving about 3 cm. • Bead from the long end of the elastic. • Stretch the elastic just a little and tie a double-knot on the free end close to the beads (should leave about 3 cm or more). • Bead both ends through another bead. Double knot the ends together. Cut the longer piece of elastic. Toby M Horn, PhD thorn@ciw.edu

  18. Write Your DNA Sequence with Color-Coded Nucleotides A 1 18 C T G Toby M Horn, PhD thorn@ciw.edu

  19. Visit GenBank http://www.ncbi. nlm.nih.gov GenBank is celebrating its 25th Anniversary in April! Toby M Horn, PhD thorn@ciw.edu

  20. BLAST is the section of GenBank where you can search a sequence Toby M Horn, PhD thorn@ciw.edu

  21. Toby M Horn, PhD thorn@ciw.edu

  22. Scroll down to Basic BLAST Toby M Horn, PhD thorn@ciw.edu

  23. Type your sequence here Toby M Horn, PhD thorn@ciw.edu

  24. Toby M Horn, PhD thorn@ciw.edu

  25. Toby M Horn, PhD thorn@ciw.edu

  26. Toby M Horn, PhD thorn@ciw.edu

  27. Be Patient! Toby M Horn, PhD thorn@ciw.edu

  28. Confirms the number of nucleotides you entered Toby M Horn, PhD thorn@ciw.edu

  29. Graphical comparisons Toby M Horn, PhD thorn@ciw.edu

  30. Hints About the SecretSequence are Revealed Species, Location, more Toby M Horn, PhD thorn@ciw.edu

  31. Where is your sequence? Toby M Horn, PhD thorn@ciw.edu

  32. Maybe your sequence codes for protein or some other known function Toby M Horn, PhD thorn@ciw.edu

  33. The File Data Toby M Horn, PhD thorn@ciw.edu

  34. The Sequence Data Toby M Horn, PhD thorn@ciw.edu

  35. MORE Secrets in the Sequence Toby M Horn, PhD thorn@ciw.edu

  36. Resources • National Center for Biotechnology Information www.ncbi.nlm.nih.gov • Sandra Porter - Geospiza www.geospiza.com/education/ • DNA From the Beginning, CSHL www.dnalc.org • J-M Claverie & C Notredame Bioinformatics for Dummies. Wiley. 2003. Toby M Horn, PhD thorn@ciw.edu

  37. Crafts Search: beads plastic facet Beads (facet, 8 mm) and fine elastic cord • www.consumercrafts.com (Consumer Crafts) • Michaels, WalMart, BenFranklin, Jo-Ann for small quantities • www.ssww.com (S&S Wholesale for pony beads and pop-beads) Toby M Horn, PhD thorn@ciw.edu

  38. http://www.dcbiotech.orgCheck out Teaching Resources Toby M Horn, PhD thorn@ciw.edu

  39. Get your kids to dig deeper, by starting here! Toby M Horn, PhD thorn@ciw.edu

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