1 / 7

Long-Term Prognosis in Anorexia Nervosa

Long-Term Prognosis in Anorexia Nervosa. The cardiovascular implications during refeeding and after weight recovery. Mary Carter. Anorexia Nervosa (AN). Is a life-threatening illness which can be accompanied by cardiac symptoms of varying severity.

wattan
Télécharger la présentation

Long-Term Prognosis in Anorexia Nervosa

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Long-Term Prognosis in Anorexia Nervosa The cardiovascular implications during refeeding and after weight recovery Mary Carter

  2. Anorexia Nervosa (AN) • Is a life-threatening illness which can be accompanied by cardiac symptoms of varying severity. • Eighty percent of patients with an eating disorder are effected by a cardiac complication. • It has been reported that approximately one third of deaths are due to cardiac complications.

  3. Some cardiac complications • Sinus Bradycardia • Hypotension • Increased Vagal Tone • Decreased Voltage and QT Interval Prolongation • Diminished Wall Thickness • Reduced Cardiac Output

  4. During Refeeding • Experimental evidence in animals suggests that decreased compliance and diminished systolic contractility persists. • Myofibrillar destruction and edema observed in clinical and experimental starvation offers one explanation for decreased ventricular compliance.

  5. Refeeding Syndrome • Accounts for the cardiovascular decompensation seen during therapy. • It is a known complication of parenteral hyperalimentation. • Hyperalimentation produces striking hypophosphatemia. • Phosphate depletion produces wide-spread abnormalities at the cellular level.

  6. Weight Recovery • Patients showed a significant decrease in QT interval (p<.05), and QT dispersion (p<.01) • Electrocardiograms showed an increase in cardiac diameters (p<.01), left ventricular mass (p<.001), and cardiac output (p<.001). • Exercise capacity improved (0<.05) • And there was a normalization of heart rate and heart rate variability (p<.05).

  7. References • Mont, Louis, et al, “Reversibility of Cardiac Abnormalities in Adolescents With Anorexia Nervosa After Weight Recovery, Journal of American Academy of Child Psychiatry, 42:7, July, 2003. • Schochen, Douglas, et al, “Weight Loss and the Heart: Effects of AN and Starvation”, Archives of Internal Medicine, Vol. 149, April 1989.

More Related