Download
synthesis of oil of wintergreen n.
Skip this Video
Loading SlideShow in 5 Seconds..
Synthesis of Oil of Wintergreen PowerPoint Presentation
Download Presentation
Synthesis of Oil of Wintergreen

Synthesis of Oil of Wintergreen

329 Vues Download Presentation
Télécharger la présentation

Synthesis of Oil of Wintergreen

- - - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript

  1. Synthesis of Oil of Wintergreen Chemistry 1060 Laboratory

  2. Analysis • Purity determination • Thin Layer Chromatography (TLC) • Separation and identification • stationary phase – silica gel • mobile phase – organic solvent • Relative attraction to the two phases • Polarity

  3. Solvent front Rf = 3/5 = 0.60 5 cm 3 cm Origin Analysis • Thin Layer Chromatography (TLC) • Retention factor (Rf) values

  4. Analysis • Thin Layer Chromatography (TLC) • Salicylic acid (starting material) • Pure oil of wintergreen (from stockroom) • Isolated product • UV detection • Results • Isolated product • Rf pure oil of wintergreen • Salicylic acid removed?

  5. Analysis • Structure confirmation • 1H nuclear magnetic resonance (1H NMR) - or proton magnetic resonance (PMR)

  6. Analysis • 1H NMR

  7. Analysis • 1H NMR radio-frequency region of the spectrum

  8. Analysis • 1H NMR – Shielding

  9. Analysis • 1H NMR – Chemical Shifts, Chemical Equivalency tetramethylsilane (TMS)

  10. Analysis • 1H NMR – Chemical Shifts, Integration 3 1

  11. Analysis • 1H NMR – Chemical Shifts, Complex Patterns

  12. Analysis • 1H NMR – Characterizing starting material and product salicylic acid methyl salicylate

  13. Summary • GoalsWeek 1: • To synthesize methyl salicylate, or oil of wintergreen, from salicylic acid and methanol • To isolate the product using liquid-liquid extraction Week 2: • To verify the purity and identity of the product using thin layer chromatography (TLC) • To further confirm the identity of the product by nuclear magnetic resonance (NMR) spectroscopy