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Particle Based Drug Delivery Systems

Week 6. Particle Based Drug Delivery Systems. References LANGER, R.S. & PEPPAS, N.A. (1981) Present and future applications of biomaterials in controlled drug delivery systems. Biomaterials . 2 , 201-214. Solvent Casting Method. Solvent Casting Method. PROTEIN SOLUTION.

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Particle Based Drug Delivery Systems

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  1. Week 6 Particle Based Drug Delivery Systems References LANGER, R.S. & PEPPAS, N.A. (1981) Present and future applications of biomaterials in controlled drug delivery systems. Biomaterials. 2, 201-214.

  2. Solvent Casting Method

  3. Solvent Casting Method

  4. PROTEIN SOLUTION POLYMER-DCM SOLUTION ADD TO PVA IN WATER & MIX SECONDARY EMULSION (W/O/W) ULTRA SONICATION SOLVENT EVAPORATION PRIMARY EMULSION (W/O) FILTRATION AND DRYING Double Emulsion Method

  5. Spray Dried Microspheres • Inlet temperature • Polymer concentration • Pump feed rate • Aspirator ratio • Compressed air flow rate • Drug loadings

  6. F.J. Wang and C.H. Wang, “Sustained Release of Etanidazole from Spray Dried Microspheres Prepared by Non-halogenated Solvents”, J. Controlled Release, 81 263-280 (2002). Microsphere surface morphology using different polymer solution concentrations A B D C

  7. F.J. Wang, T.K.Y. Lee and C.H. Wang , “PEG Modulated Release of Etanidazole from Implantable PLGA/PDLA Discs”, Biomaterials, 23 3555-3566 (2002).. Degradation ofmicrospheres PLGA 65:35 1 month PLGA 50:50 1 month PDLA 3 month PLGA 85:15 3 month

  8. F.J. Wang, T.K.Y. Lee and C.H. Wang , “PEG Modulated Release of Etanidazole from Implantable PLGA/PDLA Discs”, Biomaterials, 23 3555-3566 (2002). Modulation of release by PEG large discs (diameter =13mm, thickness = 1mm) small discs (diameter = 5mm, thickness =1mm)

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