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Therapeutic Drug Monitoring

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  1. Therapeutic Drug Monitoring Carolyn E. Matthews RN, BSN NGR 5715 Spring 2007

  2. Therapeutic Drug Monitoring • Measure Serum Drug Levels • Narrow Therapeutic Drug Windows • Maximize Efficacy • Minimize Toxicity therapeutic toxic

  3. Theophylline Phenytoin Carbamazine Digoxin Aminoglycoside antibiotics Drugs with “Narrow Window” therapeutic toxic

  4. Sampling • Confirm toxicity – • Clinical signs of toxic levels • Adjust Dose Regimens Fatigue, Nausea…………………Psychosis, Death

  5. Steady State Concentrations • 4-5 Half-lives • Special considerations • Renal failure • Liver damage • Other medications • Food & alcohol • Loading doses • Age

  6. Peaks & Troughs • Serum levels within therapeutic range? • When to draw blood sample. www.i-base.org.uk/guides/side/levels.html