Understanding Sclerosing Adenosis with Lobular Neoplasia: Risks and Case Studies
This session covers the diagnosis and implications of sclerosing adenosis with lobular neoplasia (LISN). Based on a meta-analysis of 9 studies involving 228 patients, the risk of ipsilateral carcinoma is found to be 15%, while the contralateral risk stands at 9%. Additionally, ipsilateral breast cancer is three times more likely than contralateral. This model illustrates a premalignant condition that sits between a local precursor and a generalized risk for both breasts. Also discussed are cases of fibrocystic changes with various conditions.
Understanding Sclerosing Adenosis with Lobular Neoplasia: Risks and Case Studies
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Presentation Transcript
Diagnosis - Sclerosing adenosis with lobular neoplasia.No invasion in images provided.
Update - Risk with LISN • Meta-analysis 9 studies of 228 patients • 15% ipsilateral, 9% contralateral carcinoma • Ipsilateral 3x more likely than contralateral • A “model of premalignancy for ALH intermediate between a local precursor and a generalised risk for both breasts” • Page DL. Lancet. 2003;361:125-9
Is there a sub-group of pre-invasive LCIS? LCIS with Microinvasion • 6 LCIS with microinvasion described • Nemoto T et al. J Surg Oncol 1998; 67; 41-46
Diagnosis - Fibrocystic change with papillomas and florid usual epithelial hyperplasia
Diagnosis - Fibrocystic change with atypical lobular hyperplasia and flat high grade DCIS
