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Glecaprevir - Pibrentasvir in Non-Cirrhotic Genotype 4, 5, or 6 ENDURANCE-4

This presentation discusses the findings of the ENDURANCE-4 study on the effectiveness and safety of glecaprevir-pibrentasvir in treating treatment-naïve and treatment-experienced patients with non-cirrhotic genotype 4, 5, or 6. The study demonstrates high rates of sustained virologic response (SVR12) and provides important insights for clinicians.

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Glecaprevir - Pibrentasvir in Non-Cirrhotic Genotype 4, 5, or 6 ENDURANCE-4

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  1. Phase 3 Treatment-Naïve and Treatment-Experienced Glecaprevir-Pibrentasvir in Non-Cirrhotic Genotype 4, 5, or 6ENDURANCE-4 Source: Asselah T, et al. ClinGastroenterolHepatol. 2018;16:417-26.

  2. Glecaprevir-Pibrentasvirin Non-Cirrhotic Genotype 4, 5, or 6*ENDURANCE-4: Study Features *Note: ENDURANCE-4 was published in conjunction with ENDURANCE-2 and SURVEYOR-II (Part 4) Source: Asselah T, et al. ClinGastroenterolHepatol. 2018;16:417-26.

  3. Glecaprevir-Pibrentasvirin Non-Cirrhotic Genotype 4, 5, or 6ENDURANCE-4: Study Design 0 12 24 Week Glecaprevir-Pibrentasvir(n = 121) GT 4, 5, 6 No cirrhosis SVR12 Drug DosingGlecaprevir-pibrentasvir (100/40 mg) fixed dose combination; three pills once daily Source: Asselah T, et al. ClinGastroenterolHepatol. 2018;16:417-26.

  4. Glecaprevir-Pibrentasvirin Non-Cirrhotic Genotype 4, 5, or 6ENDURANCE-4: Baseline Characteristics Source: Asselah T, et al. ClinGastroenterolHepatol. 2018;16:417-26.

  5. Glecaprevir-Pibrentasvirin Non-Cirrhotic Genotype 4, 5, or 6ENDURANCE-4: Baseline Characteristics Source: Asselah T, et al. ClinGastroenterolHepatol. 2018;16:417-26.

  6. Glecaprevir-Pibrentasvirin Non-Cirrhotic Genotype 4, 5, or 6ENDURANCE-4: Results SVR12 (ITT analysis), Overall and by Genotype 50/51 51/51 50/51 50/51 120/121 75/76 26/26 19/19 Source: Asselah T, et al. ClinGastroenterolHepatol. 2018;16:417-26.

  7. Glecaprevir-Pibrentasvirin Non-Cirrhotic Genotype 4, 5, or 6ENDURANCE-4: Results SVR12 (ITT analysis), Overall and by Genotype 120/121 75/76* 26/26 19/19 *1 patient stopped drug on day 12 Source: Asselah T, et al. ClinGastroenterolHepatol. 2018;16:417-26.

  8. Glecaprevir-Pibrentasvirin Non-Cirrhotic Genotype 4, 5, or 6ENDURANCE-4: Adverse Events Source: Asselah T, et al. ClinGastroenterolHepatol. 2018;16:417-26.

  9. Glecaprevir-Pibrentasvir in Non-Cirrhotic Genotype 4, 5, or 6*ENDURANCE-4: Conclusions *Note: ENDURANCE-4 was published in conjunction with ENDURANCE-2 and SURVEYOR-II (Part 4) Source: Asselah T, et al. ClinGastroenterolHepatol. 2018;16:417-26.

  10. This slide deck is from the University of Washington’s Hepatitis C Online and Hepatitis Web Study projects. Hepatitis C Onlinewww.hepatitisc.uw.edu Hepatitis Web Studyhttp://depts.washington.edu/hepstudy/ Funded by a grant from the Centers for Disease Control and Prevention.

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