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DoH

DoH. DST. South African AIDS Vaccine Initiative (SAAVI). Established in late1999 by the South African government. Based at the Medical Research Council of South Africa (MRC). Tasked to develop an affordable, effective & locally relevant preventative HIV vaccine for southern Africa.

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DoH

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  1. DoH DST

  2. South African AIDS Vaccine Initiative (SAAVI) • Established in late1999 by the South African government. • Based at the Medical Research Council of South Africa (MRC). • Tasked to develop an affordable, effective & locally relevant preventative HIV vaccine for southern Africa. • SAAVI’s national mandates are to: • Create an enabling environment in South Africa to develop and test novel HIV vaccines. • Create opportunities for scientific and clinical collaboration with global partners.

  3. Immunology assessment Making the vaccines Testing the vaccines Animal Human Data & bioinformatics Behavioural science Actuarial assessments Community involvement Ethical issues SAAVI network

  4. Definition of an HIV vaccine • A substance that teaches the body to recognise and defend itself against HIV. • Causes a response from the immune system (the body’s defence system) preparing it to fight if exposed to the virus/bacteria at a later time. • Generally contain harmless particles or copies of particles of the virus which cannot cause HIV infection or AIDS. • Does not contain any live HI virus.

  5. SAAVI’s candidate vaccines (UCT)

  6. SAAVI’s candidate vaccines (US)

  7. Clinical trials • Two phase I clinical trials started in November 2003 at the Soweto and Durban trial sites • the VEEclade C candidate HIV-1 vaccine which is also being tested in the USA • the HIV.A MVA which has already been in trials in Kenya, the UK and Uganda • Made SA the first African country to run multiple, concurrent trials. • VEE was the first clade C vaccine to be tested in the world.

  8. Clinical trials • Two additional phase I trials are awaiting approval and could start soon • Merck’s adeno-based candidate • IAVI’s adeno-associated candidate • Three wholly South African-developed test vaccines are being manufactured for trials & have entered the regulatory approval processes (FDA). These could go to trial in 2005.

  9. Funding In addition, the European Union has awarded a grant of R10,354,500 to Masikhulisane, SAAVI’s Community Involvement Programme.

  10. MasikhulisaneSAAVI COMMUNITY INVOLVEMENT PROGRAMME VISION A South African society working in a mutually beneficial and meaningfulpartnership with researchers within a vibrant human and legal rights environment. MISSION A sustainable, accountable, learning organisation, founded on a human rights ethos, to ensure an informed and educated South African society with strengthened, active, and sustained community involvement in the AIDS vaccine development process.

  11. To promote ahuman rights culture with regard to the AIDS vaccinedevelopmentprocess To promotesustainable communityinvolvement in AIDS vaccinedevelopmentprocess To facilitate strategiccollaboration locally, regionally, &internationally oncommunity involvementin theAIDS vaccinedevelopment process To develop an effective, efficient, accountable & sustainable learning organisation To create & increase awareness of the AIDS vaccine development process Law, Human Rights & Ethics Communication, Education, Training & Development Organisational Development & Strategic Collaboration STRATEGIC GOALS KEY FOCUS AREAS

  12. European Commission Medical Research Council Contracting organisation SAAVI Management SAAVI Director Reference Group (to be established in 2005) Project Administration Administrator Masikhulisane Management Project Manager HIV Vaccine Education Vaccine Educators: KZN, Gauteng, Western Cape Law, Human Rights & Ethics Legal Advisor Communications, Education, Training Development Materials Developer Information & Knowledge Management Information Specialist Citizens, Organisations and Community Structures Organogram

  13. How we work • Nationally and provincially • In sectors such as: • NGOs, CBOs, AIDS Service organisations • Women, youth • Traditional healers • Education, health • Trade unions • In same sectors in and around the trial sites

  14. Contact details Head office Telephone: (021) 938-0552 Fax: (021) 938-0823 Medical Research Council,Francie van Zijl Drive, Parow Valley, 7505 Info-Line: 080 VAC CINE / 080 822 2463 www.saavi.org.za

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