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This document delves into the intricate signaling mechanisms of TGF-β receptors, specifically TbRI and TbRII, and their regulatory roles in cellular processes. We explore the dynamics of Xpress and cPML systems, examining their interactions and impacts on TGF-β signaling pathways. The importance of these receptors in various biological contexts, including cell proliferation and differentiation, is underscored, alongside the potential implications for therapeutic interventions targeting TGF-β signaling in disease.
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Supp. Fig. 8 IP:Xpress Input TbRII TbRI cPML Xpress-cPML cPML - - + + + + + + - - + + + + + + TbRI + - + + - - + + + - + + - - + + TbRII - + - - + + + + - + - - + + + + TGFb1 - - - + - + - + - - - + - + - +