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Regulation of DNA Cleavage and m6A Methylation by HsdR, HsdM, and HsdS Proteins

This study explores the interactions between HsdR, HsdM, and HsdS proteins in the context of DNA cleavage and methylation processes. It highlights the helical coiled-coil structures and PD-(D/E)XK motifs involved in DNA sequence recognition and translocation. Furthermore, it delves into the role of m6A methylation in regulating these enzymatic activities and provides insights into mechanisms governing DNA processing by these RecA-like proteins. Understanding these interactions could reveal new regulatory pathways in DNA manipulation.

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Regulation of DNA Cleavage and m6A Methylation by HsdR, HsdM, and HsdS Proteins

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  1. A. TspDTI 900 940 1040 1 140 350 790 1105 TRD1 TRD2 coiled coil PD-(D/E)XK RFM helical coiled coil DNA cleavage regulation? DNA m6A methylation DNA sequence recognition B. Typical HsdR (EcoR124I) 33 250 473 730 1038 RecA-like PD-(D/E)XK RecA-like C-terminal DNA cleavage interaction with HsdM/S DEAD-box module / DNA translocation C. Typical HsdM (EcoR124I) 195 478 519 9 RFM helical C-terminal dimerization DNA m6A methylation D. Typical HsdS (EcoR124I) 1 145 193 349 395 404 TRD1 TRD2 coiled coil coiled coil DNA sequence recognition

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