Quality of water in pharmaceutical industry

1. Quality of water in pharmaceutical industry

2. Water is a key element for numerous pharmaceutical and life sciences processes. As a raw material, water is used in processing, formulation and manufacturing various pharmaceutical products and active pharmaceutical ingredients (API). Most industries rely majorly on surface water and groundwater sources for their pharmaceutical purposes. In its natural state, water from these sources is not free from contamination and needs to be purified before industries use it for pharmaceutical purposes.This process of water purification involves distillation and deionization that reduces the concentration of contaminated particles, parasites, bacteria, algae, viruses, and fungi. It is imperative that water is treated using proper procedures to ensure its purity.Depending on the route of administration of the pharmaceutical product, different grades of water quality are required. Based on water quality, below are different types of water for pharmaceutical use purposes. • 1. Drinking waterDrinking water can be best described as Potable water. It may be sourced from a public water utility, a private water supply (e.g., a well) or a combination of both. Drinking water is the minimum quality of water that ought to be used for the preparation of official substances and other bulk pharmaceutical substances. The treatment required to make it safe for human consumption is determined post evaluating the condition of the source water. Drinking water, free from contamination is used for cleaning pharmaceutical manufacturing equipment and product-contact components. Some common methods of treatment include desalinization, softening, deionization, particle reduction, and reduction of inorganic and/or organic materials.The equipment and systems used to produce drinking water, their storage tanks,

3. distribution pipeworks and the water quality itself need to be routinely monitored for environmental, seasonal or supply changes which may affect the integrity of the water systems in place. Additionally, techniques such as back flushing, chemical and /or thermal sanitization should be put in place to tackle recontamination of water. • 2. Purified Water Purified water is used mainly as an excipient in the production of non-parenteral administrations and in other pharmaceutical applications. Non-parenteral is most commonly referred to as the route that oral medications are administered, therefore it is of utmost importance that water used for non-parenteral preparations must meet the requirements for ionic and organic chemical purity.Purified water is generally produced by ion exchange, reverse osmosis, and ultrafiltration. While producing purified water it is important to protect it from recontamination and other microbial protection. Water treatment company provides sterile plant in pharmaceutical industry which is useful.