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Complications of TURP. 1. Case presentation 2. TURP syndrome 3. Prevention and treatment Ri 陳昭勳. Brief History. 陳 X 傑 63 y/o male Symptoms of urinary frequency and urgency OPD follow-up and controlled by Hytrin. Past History.
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Complications of TURP • 1. Case presentation • 2. TURP syndrome • 3. Prevention and treatment Ri 陳昭勳
Brief History • 陳X傑 63y/o male • Symptoms of urinary frequency and urgency • OPD follow-up and controlled by Hytrin
Past History • Coronary artery disease s/p stenting controlled by Aspirin • Hypertension controlled by Norvasc • ASA Class III
Incidence of systemic dz in TURP patients Disease Incidence % Cardiac disease 67 Cardiovascular 50 COPD 29 DM 8
Brief History • 2 weeks ago difficulty in urination • Foley catheterizations several times • Cystostomy on 91-2-18 DC Tapal • Admission for TURP on 91-2-25
麻醉過程 • Please see 實物投影機
Irrigation Solution • Ideal: isotonic, electrically inert, nontoxic, transparent, easy to sterilize,inexpensive • Traditional: distilled water • Modern: Glycine (1.2% and 1.5) Mannitol ( 3%) Urea ( 1%)
Definition of TURP syndrome • Following complications have been reported: hypervolemia, hyponatremia, water intoxication, pulmonary edema, hemolysis, caogulopathy, bladder perforation
TURP syndrome: a problem of Volume and Solute • Intravascular volume: volume expansion and volume loss • Plasma solute: hyponatremia hypoosmolality hyperglycinemia Plasma osmolality=2xNa+Glu/18+BUN/2.8
Hyponatremia • Mechanism for hyponatremia in TURP • Na is essential for cerebral and cardiac function • <120 meq/L cardiovascular depression <115meq/L bradycardia,ECG change <100meq/L generalized seizure • Average fall in Na 3.65-10 meq/L • Incidence 7%-26%
Hypoosmolality • Derangement of CNS function due to cerebral edema • Clinical signs: decerebrate posture, positive Babinski sign, low-voltage EEG, comatose
Hemolysis • 30-70% of patients, who use water as irrigation solution • Clinical signs: chills, clammy skin, tight chest, bronchospasm • Oxygen carrying capacity decrease Free hemoglobin increase Hyperkalemia
Bladder Perforation • Caused by instrumentation, overdistension or explosion of hydrogen • Most bladder perforation is retroperitoneal • Clinical signs: return of irrigation solution decrease, abdominal distension
Prevention of TURP syndrome • Surgical technique • 術前矯正electrolyte and fluid imbalance • Special attention to cardiac p’t • Height of irrigation solution bag • Duration of surgery
Treatment of TURP syndrome • Terminate surgery • Administer Lasix • Hypertonic saline (3-5%) for hyponatremia • Intubation for pulmonary edema • Diazepam for seizure
References • Transurethral Resection of the Prostate Syndrome: A Review of the Pathophysiology and Management Anesthesia and Analgesia Feb ’97 438 • Anesthesia for Renal and Genito-Urologic surgery • Complications of Urologic Surgery
Estimation of Fluid Absorption • Serum Sodium Dilution [(Pre-Op Na)/ (Post-op Na) –1] x ECF • Breath-alcohol level • Patient’s weight gain